Abstract:

As a marker of mesenchymal cells, the transcription factor paired related homeobox 1 (Prrx1) not only participates in the bone development process during the embryonic period, but also plays a role in the adjustment of the body's bone homeostasis and the repair process after injury in adulthood. Prrx1⁺ cells are a subpopulation of the body's mesenchymal cells, which are believed to be involved in the development and formation of long bones and skulls as osteogenic precursor cells. This article reviews the role and influence of Prrx1 and Prrx1⁺ cells in bone development and bone remodeling.

Key words: paired related homeobox 1, Prrx1⁺ cells, bone development, bone remodeling

摘要：

转录因子配对相关同源框1（paired related homeobox 1，Prrx1）作为一种间充质细胞的标志物，不仅参与胚胎时期的骨发育过程，亦在机体成年后骨稳态的调节与损伤后的修复过程中发挥作用。Prrx1⁺细胞是间充质细胞的一种亚群，作为成骨的前体细胞参与骨骼的发育与形成。本文对Prrx1及Prrx1⁺细胞在骨发育及骨改建中的作用及影响进行综述。

关键词: 配对相关同源框1, Prrx1⁺细胞, 骨发育, 骨改建

CLC Number: 

• R782