Objective: To describe the clinical features, diagnosis, and treatment methods of soft tissue myxoma in oral and maxillofacial region, in order to improve the clinician's understanding of the disease. Methods: The clinical data of 56 patients with soft tissue myxoma in oral and maxillofacial region (including a 31‐year‐old female reported in this paper) were reviewed and analyzed. Results: A total of 56 patients with soft tissue myxoma in oral and maxillofacial region were included. The male to female ratio was 1.43∶1 and the average age was (37.8 ± 23.9) years. The follow‐up was unknown in 9 patients and the median follow‐up for the remaining 47 patients was 36(12~60) months. The recurrence rate was 10.6%-14.9%, and the recurrence rates at 2 years and 4 years post‐surgery were 4.3% and 8.5%, respectively. The recurrence was significantly associated with the number of lesions and treatment methods. Conclusion: Soft tissue myxoma in oral and maxillofacial region is a rare benign tumor that is easily misdiagnosed and has a high recurrence rate. It is suggested to select an appropriate surgical method according to the location of the tumors and the patient's needs. An ideal outcome is usually achieved by tumor resection with close follow‐up for more than 4 years.

Objective:The research focused on constructing the prognosticrisk score model of autophagy-related genes(ARGs) and predicting survival rate of oral squamous cell carcinoma(OSCC). Methods: Differentially expressed ARGs were retrieved from the cancer genome atlas(TCGA) database. Prognostic ARGs were identified through Cox regression and the least absolute shrinkage and selection operator(LASSO) regression analysis to construct the overall survival (OS) risk score model. Next, all casesin TCGA and GEO datasets were classified into low-risk or high-risk groups based on the median risk score. Kaplan-Meier (K-M) method was used to analyze the OS of high- and low-risk groups. In addition, the risk distribution, survival status and gene expression patterns were analyzed to demonstrate the accuracy of the risk score model. A nomogram was constructed to quantitatively estimate the survival rate of OSCC patients. Finally, differential immune cell infiltration analysis was conducted to explore the potential mechanism of the model predicting the prognosis of OSCC. Results: A total of 37 differentially expressed ARGs were screened out. 6 ARGs (BID、DDIT3、VEGFA、FADD、BIRC5、NKX2-3) were used to construct a prognostic risk score model of OSCC, which could be considered as a potentially independent prognostic factor of OSCC. The calibration curve from nomogram chart graphically verifies the consistency between the actual and predicted survival rates. Conclusions: The authors suggest that autophagy-related risk score model and nomogram constructed in this study can provide a reference for predicting the prognosis of OSCC patients, which will be helpful to understand the underlying mechanism of autophagy participating the occurrence and development of OSCC.

Objective: To investigate the effects of the related factors and Clinical treatments on the implant fracture with a typical case report. Methods: A patient with missing of left maxillary molar teeth for many years, required an implant restoration 3 years ago. The implant was fractured after loading 2 years, then the patient came to require an implant re-placement. The fractured implant were removed after a thorough clinical and radiological examination, and implant re-placement after 6 months was scheduled. Results: 6 months after removing the fractured implant, the keratinized gingiva was sufficient in the edentulous area. The implants showed excellent?osseointegration?4 months after the re-placement. Conclusion: The fracture of dental implants is a rare and serious occurrence in clinical settings, which is generally related to non-passive fitting of the prosthetic crown, overloading, design of the implant, implant metal fatigue. Complete removal of fractured implants should be considered in the clinical treatment. Implant and repair design should be considered scientifically according to the patient's situation before the implant surgery, to prevent the occurrence of implant fracture.

Objective To observe the effect of diffent extraction socket treatment methods after bone ambush mandibulai third molar were extracted. Method 299 patients with bone ambush mandibulai third molar were randomly assigned into 3 grouds. Group 1 extraction socket treatment method was directly stitched,oral analgesia+oral anti-inflammmatory. Group 2 extraction socket treatment method was stitched collagen sponge stuffing+oral analgesia+oral anti-inflammmatory. Group 3 extraction socket treatment method was stitched +collagen sponge+iodoform powder stuffing+oral analgesia+oral anti-inflammmatory. Postoperative bleeding,swelling paind and dry socket were compared between these three groups. Results Postoperative bleeding,swelling paind and dry socket had lower indcidence in groud 3 than the other two groupg 2,the prgnosis is better than the othe two groups(P<0.01). Conclusion The mothod of group 3 had safe and effective effects on the treatment of bone ambush mandibulai third molar extraction.It is worthy of fuither promotion and application in clinic.

Objective: To evaluate the clinical effect of the transcrestal around detached sinus floor elevation technique(TADSFET) in the posterior maxillary region. Methods: A total of 83 implant sites (56 patients) underwent TADSFET with bone grafting from December 2016 to July 2018.CBCT was used to measure Residual Bone Height（RBH）preoperatively.Implant was placed simultaneously or delayed according to the RBH.The elevated bone height and the integrality of the sinus membrane were evaluated by CBCT immediate postoperately.Restoration of upper structures were conducted at least 4 months after operation.The implant survival rate was evaluated during the follow-up period.Results Sinus membrane perforation was observed at 3 implant sites （3.61%）intraoperatively,lateral window sinus floor elevation technique was used to replace the TADSFET for these three implant sites.5 perforations (6.02%) were observed among the rest of 80 implant sites from CBCT immediate postoperately.For the rest of 80 implant sites 1 was given up,76 implants were placed simultaneously with sinus augmentation and 3 implants were placed in 2-stage manner.The diameter of implants was from 4.00 to 5.10mm(averaged 4.73±0.35mm) and the length of implants was from 8.00 to 11.50mm(averaged 10.27±0.69mm).The mean RBH for 75 implant sites with no sinus membrane perforation both intraoperatively and immediate postoperately was 5.57±1.91mm (ranged from 0.88 to 9.27mm) and the mean height increase of these implant sites was 8.09±1.99mm (ranged from 4.54-15.14mm).Average time between operation and permanent restoration was 7.14±2.06m (ranged from 4 to 15m) and the average follow-up period after permanent restoration was 9.36±4.60 (ranged from 1 to 20m).A total of three implants were lost,2 before and 1 after permanent restoration giving a survival rate of 96.25%.Conclusion TADSFET is a relatively invasive safe and reliable technique to lift the sinus floor.Additional cases with long period follow-up are needed to confirm the short-term results.

Objective: To study the application value of three-dimensional reconstruction visualization technique in preoperative locating and surgical planning of embedded teeth. Methods: A total of 97 patients with embedded teeth admitted between December 2017 and December 2018 were enrolled. CBCT was taken preoperatively and data in DICOM format was imported into Simplant Pro 11.0 software to construct a three-dimensional visualization model of the jaw and dentition. The positioning analysis of the impacted teeth was carried out to observe the relationship with the adjacent anatomical structures. And the surgical extraction plan was designed based on this three-dimensional visualization model. After the surgical plan was determined, the extraction operation was performed under general anesthesia according to the preoperative plan. Results: A total of 123 embedded teeth in 97 patients were successfully removed according to the preoperative design. There was no case of changing the surgical plan during operation. All patients had no complications such as nerve injury, maxillary sinus or nasal perforation, adjacent teeth injury, and abnormal bleeding. Conclusion: The three-dimensional reconstruction visualization technology is useful for accurately locating the embedded teeth and optimizing surgical extraction plan, which is worthy of clinical promotion.