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  • Case Report
    YE Zheng, SUI Fu yong, ZHANG Fu yin
    《Journal of Oral and Maxillofacial Surgery》.
    Accepted: 2025-06-27

    The parotid gland is the anatomical site with the highest incidence of salivary gland tumours, and its complex anatomical structure places high demands on surgical precision.In this paper, we report a case of precise resection of a deep lobe tumour of the parotid gland by applying the surgical navigation (SN) system.With the SN system, complete preservation of important neurovascularity around the tumour was achieved intraoperatively, and the patient recovered well after surgery.This case confirms that the SN system has good clinical value in the resection of deep lobe tumour of parotid gland.

  • Clinical Study
    SIQIN Gaowa , LI Chenxi, HUANG Dishu , WANG Yue , GONG Zhongcheng
    《Journal of Oral and Maxillofacial Surgery》.
    Accepted: 2025-06-12
    Objectives: To evaluate the clinical prognostic factors affecting the recovery of patients suffered from Bell´s palsy. Methods: Clinical materials from 95 patients that were admitted to the two principal hospitals in Xinjiang Uygur Autonomous Region between January 2010 and January 2024 due to Bell’s palsy were retrospectively analyzed. In addition to assessing
    patient’s demographic characteristics, the independent risk factors that could affect clinical prognosis for patients were identified by performing multivariate logistic regression model. The effectiveness of model was assessed by analyzing the receiver operator characteristic (ROC) curve and calculating the area under the curve (AUC). Results: Patients aged from 28 to 77 (average 49.30 ± 6.96) year-old were included, with females (54.7%) and patients over 50 years old (51.6%)
    being the majority. Smoking (P = 0.014), hypertension (P = 0.041), diabetes mellitus (P = 0.049) and higher H-B grade (P < 0.001) were associated with incomplete recovery of patients. There was no statistically significant difference (P > 0.05) in the recovery of patients with facial paralysis between receiving physical therapy and different pharmacological interventions.
    According to multivariate logistic regression analyses, the presence of smoking (OR = 3.90, P = 0.018), hypertension (OR = 3.02, P = 0.047) and higher H-B grade (OR = 0.11, P = 0.006) were independent prognostic factors for partial recovery in patients with Bell´s palsy. These three parameters indicated good predictive value for poor clinical prognosis in patients with Bell´s palsy, with AUCs of 0.88, 0.84 and 0.81, respectively. Conclusion: Patients treated with corticosteroids alone or in combination with antivirals showed no significant difference in the recovery rate. Similarly, no statistically significant difference was observed between patients who received physiotherapy and those who did not. Smoking, hypertension, and higher House-Brackmann grade were significantly associated with patients’ poor prognosis, such as partial recovery.
  • Review
    ZHANG Zhanwei, YU Yiqiang, SU Jiansheng
    《Journal of Oral and Maxillofacial Surgery》.
    Accepted: 2025-05-22

    Cell membrane-coated nanoparticles (CMCNPs) are a class of nanoscale carriers enveloped by natural cell membranes, which efficiently preserve the abundant functional proteins and receptors on the surface of cell membranes, thereby integrating the biological properties of natural cell membranes and demonstrating excellent biocompatibility and precise targeting ability in the field of biomedicine. In treating various oral diseases, such as oral cancer and periodontitis, CMCNPs have shown great potential and provide new research directions for overcoming oral medicine problems, emerging as one of the forefront topics in current biomedical research. This paper focuses on CMCNPs, presenting a detailed review of their preparation techniques and research progress in treating oral diseases. This article focuses on CMCNPs and deeply explores relevant mechanisms, application results and existing challenges, aiming to provide scientific and precise references for the subsequent academic research and clinical translation of oral diseases such as oral cancer, periodontitis, and oral mucosal diseases.

  • Clinical Study
    Aishan·Yilihamu, Keranmu·Abasi, WEI Yiru, XUJun
    《Journal of Oral and Maxillofacial Surgery》.
    Accepted: 2025-05-16

    Objective: To construct a survival prognosis prediction model based on gingival carcinoma patient data from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute in the United States, and evaluate its effectiveness. Methods: Download relevant basic information, clinical information, and follow-up data of patients diagnosed with gingival carcinoma between 2004 and 2018 from the SEER database, and randomly divide the patients into a modeling group (70%) and a validation group (30%). Through univariate and multivariate Cox regression analysis, variables were screened to determine independent prognostic risk factors for gingival carcinoma patients, and a nomogram was constructed. Evaluate the prediction model from three perspectives: discrimination, calibration, and clinical applicability. X-Tile software was used for risk stratification of the gingival carcinoma patients. Results: This study included 3334 patients with gingival carcinoma, with 3-year, 5-year, and 10-year survival rates of 59.03%, 48.89%, and 30.69%, respectively. The concordance index (C-index) of the modeling group and validation group were 0.715 and the 0.716, respectively; The receiver operating characteristic (ROC) curve results showed that the area under the curve (AUC) for predicting the 3-year, 5-year, and 10-year overall survival rates of gingival carcinoma patients in the modeling group were 0.757, 0.759, and 0.771, respectively. In the validation group, they were 0.747, 0.765, and 0.784, respectively. The C-index and AUC of the nomogram were higher than those of the traditional TNM staging system (P<0.001). The calibration curve results indicate that the nomogram model has good predictive accuracy. The decision curve analysis (DCA) results show that the nomogram has good clinical application value and is superior to the traditional TNM staging system.Patients were divided into low-risk group (<116.47), medium-risk group (116.47-213.24), and high-risk group (≥213.24) based on the cutoff value of the total score in the nomogram. There was a statistically significant difference in survival rate among the three groups (P<0.001). Conclusion: Age, marital status, histological grading, T stage, N stage, surgical status, and radiotherapy status are factors affecting the survival of patients with gingival carcinoma. The nomogram prediction model constructed in this study can provide reference for predicting the prognosis of gingival carcinoma patients.

  • WANG Xin, SU Jiansheng
    《Journal of Oral and Maxillofacial Surgery》.
    Accepted: 2025-03-21
    Mammalian lipid droplets (LDs), a class of cellular organelles associated with metabolism, are composed of a neutral lipid core encapsulated by a monolayer phospholipid membrane. Initially regarded as static energy reservoirs with simplistic
    functions, recent advancements have significantly expanded our understanding of their biogenesis mechanisms and multifunctional roles. Beyond serving as central hubs for intracellular lipid metabolism, LDs actively participate in the pathogenesis of inflammatory and infectious diseases, while playing critical regulatory roles in host immune responses.
    This paper provides a review of researches in this area.
  • Review
    WANG Jin , WANG Yabin , SU Jiansheng
    《Journal of Oral and Maxillofacial Surgery》.
    Accepted: 2025-03-06
    Osteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption.Inflammation serves as a significant inducer of pathological bone resorption. Studies have shown that compared with homeostatic osteoclasts, osteoclasts that differentiate in an inflammatory microenvironment not only originate from specific osteoclast precursors, but also exhibit enhanced bone-resorbing capacity. Moreover, these inflammation-derived osteoclasts actively regulate bone destruction processes through crosstalk with stromal and immune cells. Therefore, osteoclasts in the inflammatory microenvironment are crucial for understanding the pathogenesis of inflammatory bone loss and developing targeted therapeutic strategies. This article reviews the differentiation mechanisms and functional properties
    of osteoclasts under inflammatory conditions.