《Journal of Oral and Maxillofacial Surgery》 ›› 2023, Vol. 33 ›› Issue (6): 379-384. doi: 10.12439/kqhm.1005-4979.2023.06.004

Previous Articles     Next Articles

Incidence and influencing factors of vascular pedicle ossification after the repair of maxillofacial defects by free flap: A systemic review

HU Juan()   

  1. Department of Stomatology, the Second People's Hospital of Hefei, Hefei 230000, China
  • Received:2022-04-28 Accepted:2022-11-05 Online:2023-12-28 Published:2023-12-26

游离组织瓣修复颌面部缺损后血管蒂骨化的发生率及影响因素的系统评价

胡娟()   

  1. 合肥市第二人民医院口腔科,合肥 230000
  • 通讯作者: 胡娟,主治医师. Email:hujuananhui@163.com
  • 作者简介:
    胡娟,主治医师. Email:

Abstract:

Objective: To analyze the incidence and influencing factors of vascular pedicle ossification after the repair of maxillofacial defects by free flap. Methods: Search PubMed, Web of Science and CNKI databases for keywords "pedicle ossification", "free flap" and "maxillofacial". The literatures on heterotopic ossification of free flap vascular pedicle from January 1, 2000 to December 1, 2021 were obtained. RevMan 5.4 software was used for meta analysis. Results: Five literatures were included, consisting of 829 cases in total. The incidence of heterotopic ossification of vascular pedicle visible on imaging examinations was about 11%, and the incidence of ossification with clinical symptoms was about 2%. The combined odds ratio showed that the occurrence of heterotopic ossification of vascular pedicle was significantly correlated with flap type (OR=14.01, 95%CI=3.58-54.85, P<0.001), but not with gender (OR=1.63, 95%CI=1.00-2.67, P=0.05), site of reconstruction(OR=0.90, 95%CI=0.46-1.74, P>0.05), or whether radiotherapy had been performed(OR=0.79, 95%CI=0.52-1.22, P>0.05). Conclusion: After the repair of maxillofacial defects by free flap, the incidence of heterotopic ossification of vascular pedicle visible on imaging examinations was about 11%, and the incidence of ossification with clinical symptoms was about 2%, which was mainly related to the type of free flap and mostly occurred in free fibular flap.

Key words: free flap, fibula flap, vascular pedicle ossification, repair and reconstruction, jaw bone defect

摘要:

目的:综合分析游离组织瓣修复颌面部缺损后血管蒂异位骨化的发生率及其影响因素。方法:检索PubMed、Web of Science、中国知网数据库(CNKI),关键词为“pedicle ossification”“free flap”“maxillofacial ”,检索时间为2000年1月1日至2021年12月1日的有关游离组织瓣血管蒂异位骨化的文献,采用RevMan 5.4软件进行meta分析。结果:纳入文献5篇,共计病例829例。影像学上可见的血管蒂异位骨化发生率约为11%;有临床症状的发生率约为2%。合并比值比显示,血管蒂异位骨化的发生与组织瓣类型有显著相关性(OR=14.01,95%CI=3.58~54.85,P<0.001),但其与性别(OR=1.63,95%CI=1.00~2.67,P=0.05)、重建部位(OR=0.90,95%CI=0.46~1.74,P>0.05)、是否做过放疗(OR=0.79,95%CI=0.52~1.22,P>0.05)无显著相关性。结论:游离组织瓣修复颌面部缺损后,影像学上可见的血管蒂异位骨化发生率约为11%,有临床症状的发生率约为2%。其发生主要与游离组织瓣的类型有关,多好发于游离腓骨瓣。

关键词: 游离皮瓣, 腓骨瓣, 血管蒂骨化, 修复重建, 颌骨缺损

CLC Number: