Abstract: Objective: To summarize a more effective method to prevent  postoperative nausea and vomiting (PONV) of oral and  maxillofacial operations. Methods:  80 patients after oral and maxillofacial surgery were randomly divided into two groups. In group A (A+T), atropine preoperatively and tropisetron postoperatively were used. In group B (P+T), penehyclidine preoperatively and tropisetron postoperatively were used. All measurement results were expressed as means ± SD, chi-aquare test was used for proportions and significance was set at P< 0.05. Statistical analyses were performed with SPSS 13.0 software. Results: VAS scores of nausea in group A during anesthesia recovery period were significantly higher than those in group B (P<0.05). The occurrence of PONV in group B was lower than those in group A (P<0.05). Conclusion: Penehyclidine preoperative combined with tropisetron postoperative application show an obvious prevention and treatment effects of PONV after operation of oral and maxillofacial surgery.

Key words:  penehyclidine, tropisetron, postoperative nausea and vomiting (PONV), oral and maxillofacial surgery

摘要： 目的： 寻找一种对口腔颌面外科术后恶心呕吐有更强防治作用的方法。方法： 40例口腔颌面外科手术患者术前用阿托品、手术结束用托烷司琼为A+T组；另40例术前用戊乙奎醚、手术结束用托烷司琼为P+T组。结果： 麻醉恢复期24 h内，恶心VAS评分，A+T组高于P+T组（P<0.05）；呕吐百分比A+T组明显高于P+T组（P<0.05）。结论： 口腔颌面外科手术患者，术前戊乙奎醚、术后托烷司琼的联合用药，能更好地防治术后恶心呕吐。

关键词: 戊乙奎醚, 托烷司琼, 恶心呕吐, 口腔颌面外科

CLC Number: 

• R782.054