Abstract: Objective：To observe the clinical effects of periocline on acute pericoronitis. Methods: 83 cases of acute pericoronitis of wisdom teeth were randomly divided into two groups. Experiment group (n=39), tooth pocket were rinsed by 3% hydrogen dioxide solution and saline water and then  periocline ointment was applied into the pocket. Comparison group (n=44), after the pocket was rinsed, 2% iodine-glycerin was applied, and combined with oral administration of antibiotics for 3 days. Therapeutic effects between the two groups were assessed 3 days later after treatment. Results: The cure rate of acute pericoronitis in experiment group and comparison group were 56.42% and 29.55% respectively. The effective rate in experiment group and comparison group were 89.74% and 70.45% respectively. There was an obvious statistical difference (P<0.05). Conclusion: Periocline is effective and safe in treatment of acute pericoronitis．

Key words: acute pericoronitis, periocline, therapeutic effect

摘要： 目的：观察米诺环素（派丽奥）软膏治疗智齿冠周炎的效果。 方法：选取急性智齿冠周炎83例，随机分为实验组(n=39)和对照组(n=44)。实验组经3%过氧化氢液和生理盐水交替冲洗冠周后，将派丽奥软膏注入智齿冠周盲袋内；对照组经冠周冲洗后，将2%碘甘油置入盲袋内并口服抗生素（头孢拉定 0.25 g/次，4次/d，连续服用3 d）。3 d后复诊评价疗效。 结果：实验组的痊愈率(56.42%)和总有效率(89.74%)均较对照组(29.55%，70.45%)高，差异均有统计学意义(痊愈率：χ²=6.12，P<0.05；治愈率：χ²=4.72，P<0.05)。两组均无不良反应发生。 结论：派丽奥软膏是一种高效安全、操作简单的治疗智齿冠周炎的局部缓释药物。

关键词: 急性智齿冠周炎, 派丽奥, 疗效

CLC Number: 

• R782.31