《Journal of Oral and Maxillofacial Surgery》 ›› 2017, Vol. 27 ›› Issue (3): 157-160. doi: 10.3969/j.issn.1005-4979.2017.03.002

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The Expression Pattern of Fibulin-7 in the Development Process of Murine Mandibular Condyles

OuYang-Ning-Juan , LI  Hong-Liang, LIN  Yu-Heng, WANG  Min-Jiao, SHEN  Guo-Fang, DAI  Jie-Wen   

  1. Department of Cranial and Oral Maxillofacial Science, Shanghai Ninth People’s Hospital,
    College of Stomatology, School of Medicine, Shanghai Jiaotong University,
    Shanghai Key Laboratory of Stomatology
  • Received:2016-07-27 Revised:2017-01-15 Online:2017-06-28 Published:2018-05-09

Fibulin-7在小鼠下颌骨髁突发育过程中的表达变化

  欧阳宁鹃, 李洪亮, 林雨恒, 王敏娇, 沈国芳, 代杰文   

  1. 上海交通大学医学院附属第九人民医院口腔颅颌面科
  • 通讯作者: 代杰文,主治医师,副研究员. 沈国芳,主任医师. E-mail:daijiewen@163.com; maxillofacsurg@163.com
  • 作者简介:欧阳宁鹃(1990—),女,上海人,博士研究生. E-mail: oynjc0508@163.com
  • 基金资助:

    国家自然科学基金(81300842、81570947);上海高校创新团队计划;上海高校高峰高原学科建设项目

Abstract: Objective: To investigate the expression patterns of Fibulin-7 in murine mandibular condyles at different developmental stages. Methods: Mandible samples of C57BL/6J mice of embryonic day 15.5, postnatal day 1 and day 28 were collected. The expressions of Fibulin-7 in murine mandibular condyles were detected by immunohistochemistry staining. Results: The expression of Fibulin-7 was detected in the development process of mandibular condyles, and gradually migrated to layers where the mature chondrocytes locate, and also to cell membrane and mesochondrium. Conclusion: Fibulin-7 was expressed at different locations in diverse developmental stages of mandibular condyles, indicating their individual functions in the process of the maturation of condyle cartilages.

Key words: Fibulin-7, mouse, mandibular condyles, expression patterns

摘要: 目的:观察Fibulin-7蛋白在下颌骨髁突发育过程中的时空表达特点。方法:取胚胎第15.5 d、出生后第1 d、出生后第28 d的C57BL/6J小鼠下颌骨标本,应用免疫组织化学方法检测Fibulin-7在下颌骨髁突软骨不同发育时期的表达情况。结果:Fibulin-7蛋白在小鼠下颌骨髁突发育过程中表达,表达情况随髁突软骨发育成熟而逐渐向成熟软骨细胞层迁移,且表达部位也随之倾向于胞膜和软骨基质中。结论:Fibulin-7蛋白在下颌骨髁突软骨发育的不同阶段皆有表达,推测Fibulin-7参与了髁突软骨分化成熟的生物学过程。

关键词:  Fibulin-7, 小鼠, 髁突, 表达变化

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