Abstract:

Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication of jaw caused by the use of anti-bone resorption and anti-angiogenesis drugs. A large amount of literature has been reported about different treatment approaches of MRONJ, ranging from conservative treatment to surgical treatment, and sometimes adjuvant therapy. However, there is no definite conclusion which specific treatment approaches should be adopted at different stages of MRONJ. This paper comments the treatment approaches at different stages of MRONJ through reviewing the related references in recent years and combining the authors′ clinical experience, thus providing a reference for clinicians.

Key words: comment, medication-related osteonecrosis of the jaw, treatment, different stages

摘要：

药物相关性颌骨坏死（medication-related osteonecrosis of the jaw, MRONJ）是一种使用抗骨吸收、抗血管生成等药物后，出现在颌骨的严重并发症。目前该病已经有大量的文献报道，并探讨了MRONJ的治疗方法，从保守治疗到不同侵袭程度的手术治疗，以及辅助治疗。但是当疾病处于不同阶段时，具体应采用何种治疗方法并没有定论。本文总结了近年相关的文献报道并结合笔者的临床经验，对不同阶段的治疗方法进行述评，以期为临床工作者提供参考。

关键词: 述评, 药物相关性颌骨坏死, 治疗方法, 不同阶段