《Journal of Oral and Maxillofacial Surgery》 ›› 2024, Vol. 34 ›› Issue (2): 81-86. doi: 10.12439/kqhm.1005-4979.2024.02.001

• Critical Review •     Next Articles

Interpretation of the WHO 2022 classification of head and neck tumours (5th Edition): The epithelial tumours of oral cavity and mobile tongue

LI Jinwei(), SHA Tong, ZHENG Kaijuan, NIE Mengdong, GUAN Weihang, SHI Ce()   

  1. Department of Oral Pathology, Hospital of Stomatology, Jilin University, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2023-12-03 Accepted:2024-01-24 Online:2024-04-28 Published:2024-04-29

2022年WHO头颈部肿瘤分类(第5版)的解读:口腔和舌体上皮性肿瘤

李金薇(), 沙桐, 郑凯娟, 聂孟冬, 关苇杭, 史册()   

  1. 吉林大学口腔医院口腔病理科,吉林省牙发育及颌骨重塑与再生重点实验室,长春 130021
  • 通讯作者: 史册,教授. E-mail:ceshi@jlu.edu.cn
  • 作者简介:
    李金薇,住院医师. E-mail:
    史册,教授,主任医师,博士研究生导师。吉林大学超分子结构与材料国家重点实验室博士后;美国密西根大学牙学院访问学者。中华口腔医学会口腔病理学专业委员会常务委员;国际牙医师学院(international college of dentists,ICD)Fellow。主要从事牙和骨发育生物学与再生医学研究。主持国家自然科学基金项目3项、中国博士后科学基金特别资助项目1项、吉林省科技发展计划优秀青年人才基金项目1项、其他省级项目4项。入选吉林省高校优秀青年科研创新人才储备库、吉林大学优秀青年培育计划、吉林大学“励新优秀青年教师培养计划”(精英培养阶段)。共发表SCI收录论文30篇,其中第一作者/通信作者15篇。曾获口腔医学青年科学家论坛最具潜力奖、口腔病理杰出青年研究论坛奖、口腔生物医学新锐奖、吉林省优秀博士学位论文、“超星杯”第二届吉林省本科高校智慧课堂教学创新大赛一等奖。作为主要参加人,获省科技进步一等奖1项、省教学成果一等奖1项。主讲《口腔组织病理学》,作为负责人,获批第二批国家级一流本科课程(线上、线下混合式)。
  • 基金资助:
    国家自然科学基金(82270959); 国家自然科学基金(81970903); 吉林大学白求恩计划项目(2023B28); 中央高校基本科研业务费专项资金

Abstract:

The 5th edition of the Classification of Head and Neck Tumours by the World Health Organization (WHO) was published in March 2022. In the section on oral cavity and mobile tongue tumours, the classification of epithelial tumours in the 5th edition has undergone several modifications compared to the 4th edition published in 2017. Notably, oral potentially malignant disorders (OPMD) and oral epithelial dysplasia (OED) have been addressed separately, and in-depth discussions have been included regarding submucosal fibrosis (SF) and human papillomavirus (HPV)-associated oral epithelial dysplasia (HPVOED). Additionally, the section on squamous cell carcinoma (SCC) now includes carcinoma cuniculatum (CC) and verrucous carcinoma (VC), emphasizing their distinctive clinical and histological characteristics. This review provides a comprehensive overview of the most recent advancements in clinical, histological, and molecular research on epithelial tumours of oral cavity and mobile tongue since 2017.

Key words: World Health Organization, oral cavity and mobile tongue tumours, non-neoplastic lesions, epithelial tumours

摘要:

2022年3月,世界卫生组织(World Health Organization,WHO)发布了第5版《头颈部肿瘤分类》。第5版的口腔和舌体肿瘤部分中,上皮性肿瘤相较于2017年的第4版作出了一些修改,其中包括将口腔潜在恶性疾病(oral potentially malignant disorders,OPMD)和口腔上皮异常增生(oral epithelial dysplasia,OED)作了分开阐述,并详细讨论了黏膜下纤维性变(submucous fibrosis,SF)和人乳头瘤病毒(human papillomavirus,HPV)相关性口腔上皮异常增生(HPV-associated oral epithelial dysplasia,HPVOED);在鳞状细胞癌(squamous cell carcinoma,SCC)部分,介绍了穿掘性癌(carcinoma cuniculatum,CC)和疣状癌(verrucous carcinoma,VC),并阐述了其特有的临床和组织学特征。本文总结了自2017年来口腔和舌体的上皮性肿瘤相关内容在临床、组织学和分子学研究中的最新进展。

关键词: 世界卫生组织, 口腔和舌体肿瘤, 非肿瘤性病变, 上皮性肿瘤

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