Abstract:

α-ketoglutarate (AKG) is an essential intermediary metabolite of the tricarboxylic acid (TCA) cycle and amino acid metabolism. By participating in the generation of adenosine-triphosphate (ATP) and the biosynthesis of a variety of important amino acids and proteins, it is widely involved in a series of important physiological processes. Since there are few reports on the research of AKG in stomatology, this paper reviews the physiological function of AKG and its research advances in stomatology, which may lay a theoretical foundation for broadening the application of AKG in stomatology.

Key words: α-ketoglutarate, bone metabolism, epigenetics, immune regulation

摘要：

α-酮戊二酸(α-ketoglutarate，AKG)是三羧酸（tricarboxylic acid，TCA）循环以及氨基酸代谢的关键中间体，通过参与三磷酸腺苷（adenosine-triphosphate，ATP）的生成及多种重要的氨基酸和蛋白质的生物合成，广泛地参与了一系列重要的生理活动。目前AKG在口腔医学领域的研究鲜有报道。本文对AKG生理功能及其在口腔医学领域的研究进展进行综述，为拓宽AKG在口腔医学领域的应用提供理论依据。

关键词: α-酮戊二酸, 骨代谢, 表观遗传学, 免疫调节

CLC Number: 

• R782