Abstract: Objective：To observe the clinical effect of low dose of midazolam combined with lornoxicam in extraction of impacted teeth. Methods: 40 patients were randomly divided into experiment and control groups. Patients in experiment group were extracted their teeth applying midazolam combined with low dose of lornoxicam  intravenously and local anesthesia, while the control group used conventional local anesthesia. The vital signs such as systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and pulse oxygen saturation(SpO2) were measured. The sedation level (Ramsay score), the modified dental anxiety scale scores, and pain severity score (VAS) were recorded. Results: Clinical data of  SBP, DBP, HR and SpO2 in experimental group were slightly lower than those in control group. The sedation level in the experimental group was more effective. The score of modified dental anxiety scale in the experimental group was lower than that in control group after operation. The VAS in the experimental group was decreased than that in control group during mouth anesthesia after teeth extracting. Conclusion: To those patients with  dental anxiety , low dose of midazolam combined with lornoxicam show a good curative effect in impacted teeth extraction.

Key words: midazolam, lornoxicam, dental fear, impacted tooth, extraction

摘要： 目的：观察小剂量咪达唑仑复合氯诺西康在阻生齿拔除术中的临床应用效果。方法：40例需拔除下颌第三磨牙的患者随机分为研究组和对照组，研究组采用小剂量咪达唑仑复合氯诺西康静脉注射加局部麻醉法拔牙，对照组采用常规局部麻醉法拔牙。记录2组患者的收缩压（SBP）、舒张压（DBP）、心率（HR）和脉搏血氧饱和度（SpO2），并进行镇静程度（Ramsay评分）、改良牙科焦虑量表评分、疼痛程度（VAS评分）的观察。结果：研究组SBP、DBP、HR、SpO2较对照组均有轻度降低；研究组镇静程度增强（Ramsay镇静评分增高）；研究组的术后改良牙科焦虑量表评分低于对照组；研究组术前局麻时及术后VAS评分均低于对照组。结论：小剂量咪达唑仑复合氯诺西康在阻生齿拔除术中，对于极度牙科恐惧的患者具有较好的疗效。

关键词: 咪达唑仑, 　氯诺西康, 　牙科恐惧, 　阻生牙, 　牙拔除术

CLC Number: 

• R782.11