Abstract: Objective: To find and confirm the effective antimicrobial agents in the treatment of intractable chronic parotiditis. Methods: 43 patients who suffered from chronic intractable parotiditis and 10 healthy control subjects were consisted in this study. Secretions were collected from Stensen′s duct and sent to laboratory immediately for cultivation and identification of pathogenic anaerobes. Standardized disk-agar diffusion method was used for determining susceptibility to antibiotics. Results: The sensitive rate of ampicillin / sulbactam which were seldom used in clinical practice was the highest in the susceptibility test, followed by gentamicin and nitrofurans. A certain degree of the drug resistance was found in commonly used penicillin and the first and second generation of cephalosporin. The most resistance was found in cefradine. Conclusion: This survey indicates pathogenic anaerobes in intractable chronic parotid infection show more susceptibility to ampicillin / sulbactam.

Key words: intractable parotitis, anaerobic bacterium, anaerobic culture, drug sensitive test

摘要： 目的：明确难治型慢性腮腺炎导管内厌氧菌的敏感抗生素，以指导临床药物治疗。方法：收集43例经反复导管冲洗及药物治疗的慢性阻塞性腮腺炎患者，通过厌氧培养系统对43例顽固性腮腺慢性炎症患者的导管脓性分泌物及10例健康对照组进行厌氧培养，同时进行抗生素药敏试验。结果：目前临床较少应用的氨苄西林/舒巴坦敏感率最高，其次为庆大霉素、呋喃类药物；对青霉素和第1、2代头孢菌素等临床普遍应用的药物均有一定程度的耐药性，尤以头孢拉定最为明显。结论：难治性腮腺炎导管内的厌氧菌，对临床常用的抗生素均产生不同程度的耐药性，而对不常应用的抗生素敏感性较高。

关键词: 难治型腮腺炎,  ,  , 厌氧培养,  ,  , 抗生素,  ,  , 药敏

CLC Number: 

• R781.72