《Journal of Oral and Maxillofacial Surgery》

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Dynamic Osteogenesis of nFA/PEEK in Early Stress Testing

YAN Wu-mao, CHEN Qin, WEI Jie, MA Jian   

  1. 1. School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072;
     2. Institute of Materials Science, East China University of Science and Technology, Shanghai 200237, China
  • Online:2017-10-28 Published:2019-03-26

延期负载下nFA/PEEK种植材料的骨结合情况动态观察

严乌毛,   陈卿,   魏杰,   马健   

  1. 1. 上海牙组织修复与再生工程技术研究中心,同济大学口腔医学院,上海 200072;
    2. 华东理工大学材料学院,上海   200237
  • 通讯作者: 马健,教授. E-mail: jian.ma@tongji.edu.cn
  • 作者简介:严乌毛(1991—),女,安徽安庆人,硕士研究生. E-mail: 6826windy@tongji.edu.cn
  • 基金资助:
    上海市科学技术委员会生物医药处医学引导类项目(15411963000)

Abstract:

Objective: To investigate and evaluate osteogenesis, which nano-fluorapatite polyetheretherketone (nFA/PEEK) implant materials were in the condition of early loading. Methods: Each 10 of PEEK, nFA/PEEK and Ti implants were installed in mandible premolar area of 10 beagle dogs, and then those resin crowns was applied after 2-month healing. Each 5 dogs were randomly sacrificed at the end of 3- and 6-months. Implants and their undecalcified bone tissues were examined by X-ray and CBCT examination. The bone implant contacts (BIC) were measured after HE staining while the mineralization apposition ratio (MAR) were labeled by fluorochromes. Results: nFA/PEEK implant was clearly seen in X-ray and CBCT. At the end of third month, MAR in nFA/PEEK (1.70±0.65) was not found to be significantly lower than Ti (1.90±0.67), meanwhile, both were significantly higher than PEEK (1.37±0.42). At the end of 6th month, MAR in nFA/PEEK (1.55±0.59) was found to be significantly higher both than Ti (0.97±0.46), and PEEK (1.17±0.46). nFA/PEEK implant was found to be osseointegrated. At the end of third month, BIC of Ti (71.24%, Median) was not found to be significantly higher than nFA/PEEK (44.96%), which both of them were significantly higher than PEEK (36.08%). At the end of 6th month, BIC of Ti (83.77%) was not found to be significantly higher than nFA/PEEK (76.13%), which both of them were significantly higher than PEEK (56.62%). Conclusions: nFA/PEEK implants show higher biocompatibilities. The results of our study may have potential clinical benefits.

Key words:  , nFA/PEEK, implant, osseointegration, early loading

摘要:

目的:探究延期负重加载条件下纳米氟磷灰石/聚醚醚酮(nFA/PEEK)新型种植材料骨结合效能研究。方法:各10枚PEEK、nFA/PEEK和钛种植体延期植入10条比格犬下颌骨前磨牙区,2个月后树脂冠修复并于3个月末和6个月末随机处死,非脱钙种植体骨组织行X线和CBCT检查,切片HE染色测定骨结合率(bone-to-implant percentage,BIC),荧光标记测定骨矿化沉积率(mineral apposition rate,MAR)。结果:nFA/PEEK种植体影像清晰,3个月末nFA/PEEK的MAR(1.70±0.65) μm/d低于钛(1.90±0.67) μm/d,且两者差异无统计学意义,但nFA/PEEK和钛的MAR均明显高于PEEK(1.37±0.42) μm/d。6个月末nFA/PEEK的MAR(1.55±0.59) μm/d与钛(0.97±0.46) μm/d比较,差异有统计学意义,均明显高于PEEK(1.17±0.46) μm/d。nFA/PEEK与牙槽骨形成良好骨结合。3个月末钛的BIC(71.24%,中位数)与nFA/PEEK(44.96%)、PEEK(36.08%)间,差异均有统计学意义。6个月末钛的BIC(83.77%)高于nFA/PEEK(76.13%)但差异无统计学意义,均明显高于PEEK(56.62%)。结论:nFA/PEEK具有良好生物相容性,具有未来临床应用价值。

关键词: 氟磷灰石/聚醚醚酮;  , 种植体;  , 骨结合;  , 早期负重

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