《Journal of Oral and Maxillofacial Surgery》

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Clinical Significance of XIAP Expression in Human Oral Squamous Cell Carcinoma

WU Sheng-li1, OU YANG-yibo2, LI Jun1, XU Jian-hui1, HU Qin-gang3, YANG Xi-hu1,3   

  1. 1. Department of Oral and Maxillofacial Surgery, Jiangsu University Hospital, Zhenjiang 212001; 2. Department of Orthopaedics, Zhenjiang Municipal 4th Peoples' Hospital, Zhenjiang 212001; 3. Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Medicine, Nanjing University, Nanjing 210000, Jiangsu Province, China
  • Online:2018-02-28 Published:2019-04-16

X连锁凋亡抑制蛋白在口腔鳞癌组织中的表达及临床意义

吴胜利1, 欧阳艺波2, 李 俊1, 许建辉1, 胡勤刚3, 杨细虎1,3   

  1. 1. 江苏大学附属医院口腔科,江苏 镇江 212001;2. 镇江市第四人民医院骨科,江苏 镇江212001;3. 南京大学医学院附属口腔医院口腔颌面外科,江苏 南京 210000
  • 通讯作者: 杨细虎,主治医师. E-mail: yangxihu1981@126.com.
  • 作者简介:吴胜利(1976—),女,江苏镇江人,主治医师,学士.E-mail: 547061684@@qq.com
  • 基金资助:
    江苏省青年医学人才项目(QNRC2016841);镇江市卫生科技重点项目(SHW2015003);江苏大学附属医院新技术新项目基金(121)

Abstract: Objective: To investigate whether the expression of X—linked inhibitor of apoptosis protein(XIAP)are related to the biological behavior of human oral squamous cell carcinoma(OSCC). Methods: A retrospective study of 52 OSCC patients. The expression of XIAP was examined by IHC. XIAP expression level and pathological parameters of OSCC were evaluated. Results: XIAP positive expression was detected in 14(27%) cases. XIAP expression level manifested a positive correlation with the degree of tumor differentiation of OSCC. There was a significant correlation between the XIAP expression and the prognosis of patients. Conclusion: XIAP may play an important role in the tumorigenesis and development of human oral squamous cell carcinoma, XIAP expression level may be a valuable predictor for the estimation of prognosis of OSCC patients.

Key words: X—linked inhibitor of apoptosis protein(XIAP), oral squamous cell carcinoma, immunohistochemistry

摘要: 目的:探讨X连锁凋亡抑制蛋白(XIAP)在口腔鳞癌中的表达及其与患者预后之间的关系。方法:运用免疫组化技术检测52例口腔鳞癌组织标本中XIAP蛋白的表达情况,评价其表达水平和患者各临床病理参数及患者预后之间的关系。结果:纳入研究的52例临床标本中XIAP阳性表达14例(27%)。XIAP表达水平与病理分级相关,并且和患者预后显著相关。结论:XIAP蛋白可能参与了口腔鳞癌的发生发展,并且与患者预后密切相关。

关键词: X连锁凋亡抑制蛋白(XIAP), 口腔鳞状细胞癌, 免疫组织化学

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