Abstract:
Objective: To study concentrations of 5-FU in tongue and submandibular lymph nodes by using different infusion methods. Methods： Sixteen dogs were divided randomly into two groups, Group A was used intra-lingual arterial drug infusion and Group B was femoral vein drug infusion. 5-FU was continuously infused to lingual artery by superficial temporal artery retrograde intubation and femoral vein by micro-infusion pump, respectively. The ipsilateral tongue and submandibular lymphatic nodes were harvested at 12 h, 24 h. The concentration of 5-FU in tissues at different time point were determined by PR-HPLC. Results： The dogs could withstand 24 h continuous 5-FU infusion through lingual artery under general anesthesia and maintain stable vital signs. The drug concentration in ipsilateral tongue and submandibular lymphatic nodes by intra-lingual arterial infusion was much higher than that of femoral vein infusion. Conclusion: 5FU concentrations in submandibular lymph nodes and tongue using continuous lingual artery infusion found to be much higher than that of femoral vein infusion.
Key words:
continuous lingual artery infusion,
continuous femoral vein infusion,
5-FU,
tongue tissue,
submandibular lymph nodes,
dogs
摘要： 目的：比较不同方法灌注5-FU后，犬舌及颌下淋巴结组织内的药物浓度。方法：16只健康家犬称重后随机分为A组（舌动脉给药）和B组（股静脉给药）。分别行经舌动脉及股静脉持续24 h灌注5-FU。在12、24 h采集2组灌注侧舌体组织及下颌下淋巴结。反相高效液相色谱法（RP-HPLC）检测以上采集组织标本中5-FU含量。结果：全麻状态下，犬能耐受24 h舌动脉持续灌注5-FU并保持生命体征平稳。舌动脉灌注组舌体组织及颌下淋巴结内5-FU浓度，明显高于股静脉给药组。结论：5-FU舌动脉持续灌注后，舌及下颌下淋巴结的药物浓度均明显高于股静脉持续灌注。
关键词:
舌动脉持续灌注； ,
股静脉持续灌注； ,
5-FU；舌体组织； ,
颌下淋巴结； ,
犬
CLC Number:
QIAO Xin-jin1, YI Jie2, HU Xiao-hua2, ZHANG Ni-ni2, HUANG Gui-lin2. Drug Concentration in Tissues of Head and Neck by Using Different Infusion Methods with 5-FU[J]. 《Journal of Oral and Maxillofacial Surgery》, 2013, 23(6): 424-426.
乔薪瑾1， 易杰2， 胡晓华2， 张霓霓2， 黄桂林2. 二种途径灌注5-FU犬头颈部药物浓度的变化比较[J]. 《口腔颌面外科杂志》, 2013, 23(6): 424-426.