Abstract: Objective: To investigate the incidence of occult micrometastasis in level IIb associated with cN0 oral squamous cell carcinoma (OSCC). Methods: A total of 419 cervical lymph nodes from 94 patients were included in this study. All lymph nodes were re-examined by anti-cytokeratin (CK) immunohistochemical staining combined with semiserial sections. Results: Among the 419 cervical lymph nodes, CK staining identified metastatic carcinoma in two cases, which showed carcinoma metastasis simultaneously on routine pathological examination. Among the 417 pathological negative lymph nodes, two metastases (1.0 mm×0.5 mm and 0.7 mm×0.8 mm) were detected by CK staining in only one lymph node in level IIb harboring. Conclusion: The incidence of level Ⅱb lymph nodes metastasis was very low for patients with cN0 OSCC, so it is unnecessary to dissect level Ⅱb lymph nodes in patients with early cN0 OSCC.

Key words: oral squamous cell carcinoma, level IIb lymph node；micrometastasis

摘要： 目的：探讨cN0口腔鳞癌患者颈部Ⅱb区淋巴结的微小转移情况。方法：对94例cN0口腔鳞癌患者颈部淋巴结清扫术后标本中的419枚Ⅱb区淋巴结半连续切片，进行角蛋白免疫组化染色检查分析。结果：419枚Ⅱb区淋巴结中，常规病理检查为阳性的2枚转移淋巴结，角蛋白免疫组化染色检查结果均呈阳性；其余417枚常规病理检查为阴性的淋巴结中，仅有1枚淋巴结发现了两处约为1.0 mm×0.5 mm及0.7 mm×0.8 mm大小的微小转移灶。结论：cN0口腔鳞癌颈部Ⅱb区淋巴结的转移率很低，建议早期cN0口腔鳞癌患者行择区性颈淋巴结清扫术时保留颈部Ⅱb区淋巴组织。

关键词: 口腔鳞癌,  ,  , Ⅱb区淋巴结,  ,  , 微小转移

CLC Number: 

• R782

• R739.8