摘要：

细胞膜包被纳米颗粒（cell membrane-coated nanoparticles，CMCNPs）是一类利用天然细胞膜包裹的纳米级载体，能够高效保留细胞膜表面丰富的功能蛋白及受体，从而整合天然细胞膜的生物学特性，在生物医学领域显示出良好的生物相容性和靶向能力。在口腔癌、牙周炎等多种口腔疾病的治疗中，CMCNPs显示出良好的应用潜能，为攻克口腔医学相关难题提供了新的研究方向，已成为当下生物医学研究的热点之一。本文聚焦于CMCNPs，深入探讨相关机制、应用成果及现存挑战，旨在为口腔癌、牙周炎、口腔黏膜病等口腔疾病的学术研究及临床转化提供参考。

关键词: 细胞膜包被纳米颗粒, 口腔癌, 牙周炎

Abstract:

Cell membrane-coated nanoparticles (CMCNPs) are a class of nanoscale carriers enveloped by natural cell membranes, which efficiently preserve the abundant functional proteins and receptors on the surface of cell membranes, thereby integrating the biological properties of natural cell membranes and demonstrating good biocompatibility and targeting ability in the field of biomedicine. In treating various oral diseases such as oral cancer and periodontitis, CMCNPs have shown good potential and provided new research directions for overcoming related challenges in oral medicine, emerging as one of the forefront topics in current biomedical research. This paper focuses on CMCNPs and explores in depth the relevant mechanisms, application achievements, and existing challenges, aiming to provide a reference for the academic research and clinical translation of oral diseases such as oral cancer, periodontitis, and oral mucosal diseases.

Key words: cell membrane-coated nanoparticles, oral cancer, periodontitis