《Journal of Oral and Maxillofacial Surgery》 ›› 2016, Vol. 26 ›› Issue (5): 368-. doi: 10.3969/j.issn.1005-4979.2016.05.014

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Recent Advances of Nervous System on Bone Remodeling

PAN Min, SUN Yao   

  1. Department of Implantology, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration
  • Received:2016-03-28 Revised:2016-04-19 Online:2016-10-28 Published:2017-06-30

神经系统对骨代谢的影响

潘敏(综述),孙瑶(审校)   

  1. 同济大学口腔医学院·同济大学附属口腔医院口腔种植科,上海牙组织修复与再生工程技术研究中心
  • 通讯作者: 孙瑶,教授. E-mail: sunyao919@126.com E-mail:sunyao919@126.com
  • 作者简介:潘敏(1991—),女,陕西人,硕士研究生. E-mail: 15000159931@163.com
  • 基金资助:

    国家自然基金(81300840);国家自然基金(81470715);高等学校博士学科专项科研基金(20130072120024);上海市卫生和计划生育委员会科研课题(XYQ2013080);国家重点研发计划课题(2016YFC1102705)

Abstract: Bone metabolism and bone homeostasis is maintained by bone resorption and bone formation. In recent years, a growing number of studies have found that bone development, bone metabolism, bone repair, and bone regeneration were also under the control of nervous system. The nervous system can regulate bone metabolism by neurotransmitterand its extensive  peripheral nerve synapses. Here, we review of how does the nervous system regulate bone deveolpment and metabolism, such as sympathetic nerve, sensory nerve, the central nervous system, serotonin, leptin, substance P, calcitonin gene?鄄related peptide, and SEMA.

Key words:  the nervous system, bone matabolism, osteoporosis

摘要: 骨代谢和骨的内稳态是由骨吸收和骨形成两个过程共同维持的。近年来,越来越多的研究发现,神经系统参与骨发育、骨代谢的调节,以及骨的修复与再生。神经系统对骨代谢的调控主要是通过其分泌的神经递质及其广泛的外周神经突触实现的。在此,我们针对神经系统如何调节骨发育和骨代谢这一问题加以综述。主要内容包括交感神经、感觉神经和中枢神经系统的作用;血清素、瘦素、P物质、降钙素基因相关肽、SEMA等神经递质的作用机制。

关键词: 神经系统, 骨代谢, 骨质疏松症

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