Recent Advances of Nervous System on Bone Remodeling

doi:10.3969/j.issn.1005-4979.2016.05.014

Abstract

Abstract: Bone metabolism and bone homeostasis is maintained by bone resorption and bone formation. In recent years, a growing number of studies have found that bone development, bone metabolism, bone repair, and bone regeneration were also under the control of nervous system. The nervous system can regulate bone metabolism by neurotransmitterand its extensive peripheral nerve synapses. Here, we review of how does the nervous system regulate bone deveolpment and metabolism, such as sympathetic nerve, sensory nerve, the central nervous system, serotonin, leptin, substance P, calcitonin gene?鄄related peptide, and SEMA.

Key words: the nervous system, bone matabolism, osteoporosis

摘要： 骨代谢和骨的内稳态是由骨吸收和骨形成两个过程共同维持的。近年来，越来越多的研究发现，神经系统参与骨发育、骨代谢的调节，以及骨的修复与再生。神经系统对骨代谢的调控主要是通过其分泌的神经递质及其广泛的外周神经突触实现的。在此，我们针对神经系统如何调节骨发育和骨代谢这一问题加以综述。主要内容包括交感神经、感觉神经和中枢神经系统的作用；血清素、瘦素、P物质、降钙素基因相关肽、SEMA等神经递质的作用机制。

关键词: 神经系统, 骨代谢, 骨质疏松症

CLC Number:

R782

PAN Min, SUN Yao. Recent Advances of Nervous System on Bone Remodeling[J]. 《Journal of Oral and Maxillofacial Surgery》, 2016, 26(5): 368-.

潘敏(综述)，孙瑶（审校）. 神经系统对骨代谢的影响[J]. 《口腔颌面外科杂志》, 2016, 26(5): 368-.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2016.05.014

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2016/V26/I5/368

References

[1] Bonnet N, Pierroz DD, Ferrari SL. Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis[J]. J Musculoskelet Neuronal Interact, 2008, 8(2):94-104.
[2] Elefteriou F, Campbell P, Ma Y. Control of bone remodeling by the peripheral sympathetic nervous system[J]. Calcif Tissue Int, 2014, 94(1):140-151.
[3] Huang HH, Brennan TC, Muir MM, et al. Functional alpha1-and beta 2-adrenergic receptors in human osteoblasts[J]. J Cell Physiol, 2009, 220(1):267-275.
[4] Suzuki A, Palmer G, Bonjour JP, et al. Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells[J]. Endocrinology, 1999, 140(7):3177-3182.
[5] Kellenberger S, Muller K, Richener H, et al. Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating beta2-adrenergic receptors[J]. Bone, 1998, 22(5):471-478.
[6] Komoto S, KondoH, Fukuta O, et al. Comparison of β-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast[J]. Chronobiol Int, 2012, 29(1):66-74.
[7] Arai M, Nagasawa T, Koshihara Y, et al. Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells[J]. Biochim Biophys Acta, 2003, 1640(2-3):137-142.
[8] Kondo H, Takeuchi S, Togari A. β-adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species[J]. Am J Physiol Endocrinol Metab, 2013, 304(5):E507-E515.
[9] Elefteriou F. Regulation of bone remodeling by the central and peripheral nervous system[J]. Arch Biochem Biophys, 2008, 473(2):231-236.
[10] Aitken SJ, Landao-Bassonga E, Ralston SH, et al. Beta-2 adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms[J]. Arch Biochem Biophys, 2008, 482(1-2):96-103.
[11] Li H, Fong C, Chen Y, et al. beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling[J]. Arch Biochem Biophys, 2010, 496(2):77-83.
[12] 王承勇, 林海, 王锦,等. 失交感神经支配与新骨形成及改建[J]. 福建医科大学学报, 2014,48(1):29-33.
[13] Farr JN, Charkoudian U, Barnes JN, et al. Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women[J]. J ClinEndocrinol Metab, 2012, 97(11):4219-4227.
[14] Bajayo A, Bar A, Denes A, et al. Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual[J]. Proc Natl Acad Sci, 2012, 109(38):15455-15460.
[15] Lips KS, Kauschke V, Hartmann S, et al. Cholinergic nerve fibers in bone defects of a rat osteoporosis model and their regulation by implantation of bone substitution materials[J]. J Musculoskelet Neuronal Interact, 2014, 14(2):173-188.
[16] Adamus MA, Dabrowski ZJ. Effect of the neuropeptide substance P on the rat bone marrow-derived osteogenic cells in vitro[J]. J Cell Biochem, 2001, 81(3):499-506.
[17] An YS, Lee E, Kang MH, et al. Substance P stimulates the recovery of bone marrow after the irradiation[J]. J Cell Physiol, 2011, 226(5):1204-1213.
[18] Wang L, Zhao R, Shi X, et al. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro[J]. Bone, 2009, 45(2):309-320.
[19] Sun HB, Chen JC, Liu Q, et al. Substance P stimulates differentiation of mice osteoblast through up-regulating Osterix expression[J]. Chin J Traumatol, 2010, 13(1):46-50.
[20] Shih C, Bernard GW. Neurogenic substance P stimulates osteogenesis in vitro[J]. Peptides, 1997, 18(2):323-326.
[21] Fu S, Jin D, Liu S, et al. Protective Effect of neuropeptide substance P on bone marrow mesenchymal stem Cells against apoptosis induced by serum deprivation[J]. Stem Cells Int, 2015, 2015:270328.
[22] Wang L, Zhao R, Shi X, et al. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro[J]. Bone, 2009, 45(2):309-320.
[23] 陀泳华. 降钙素基因相关肽(CGRP)对人脐静脉血管内皮细胞(HUVECs)的生物学效应及其机制研究[D]. 南方医科大学, 2012.
[24] Naot D, Cornish J. The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism[J]. Bone, 2008, 43(5):813-818.
[25] Yoo YM, Kwag JH, Kim KH, et al. Effects of neuropeptides and mechanical loading on bone cell resorption in vitro[J]. Int J Mol Sci, 2014, 15(4):5874-5883.
[26] Fukuda T, Takeda S. Control of bone remodeling by nervous system. Regulation of bone metabolism by appetite regulating neuropeptides[J]. Clin Calcium, 2010, 20(12):1807-1813.
[27] Elefteriou F. Neuronal signaling and the regulation of bone remodeling[J]. Cell Mol Life Sci, 2005, 62(19-20):2339-2349..
[28] Oury F, Yadav VK, Wang Y, et al. CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons[J]. Genes Dev, 2010, 24(20):2330-2342.
[29] Quiros-Gonzalez I, Yadav VK. Central genes, pathways and modules that regulate bone mass[J]. Arch Biochem Biophys, 2014, 561(6):130-136.
[30] Walther DJ, Peter JU, Bashammakh S, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform[J]. Science, 2003, 299(5603):76.
[31] Hinoi E, Gao N, Jung DY, et al. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity[J]. J Cell Biol, 2008, 183(7):1235-1242.
[32] Turner RT, Kalra SP, Wong CP, et al. Peripheral leptin regulates bone formation.[J]. JBoneMinerRes, 2013, 28(1):22-34.
[33] Ma WH, Liu YJ, Wang W, et al. Neuropeptide Y, substance P, and human bone morphogenetic protein 2 stimulate human osteoblast osteogenic activity by enhancing gap junction intercellular communication[J]. Braz J Med Biol Res, 2015, 48(4):299-307.
[34] Nunes AF, Liz MA, Franquinho F, et al. NeuropeptideY expression and function during osteoblast differentiation - insights from transthyretin knockout mice[J]. FEBS J, 2010, 277(1):263-275.
[35] Teixeira L, Sousa DM, Nunes A F, et al. NPY revealed as a critical modulator of osteoblast function in vitro: new insights into the role of Y1 and Y2 receptors[J]. J Cell Biochem, 2009, 107(5):908-916.
[36] Amano S, Arai M, Goto S, et al. Inhibitory effect of NPY on isoprenaline-induced osteoclastogenesis in mouse bone marrow cells[J]. BiochimBiophys Acta, 2007, 1770(6):966-973.
[37] Roth L, Koncina E, Satkauskas S, et al. The many faces of semaphorins: from development to pathology[J]. Cell Mol Life Sci, 2009, 66(4):649-666.
[38] Tian L, Rauvala H, Gahmberg CG. Neuronal regulation of immune responses in the central nervous system[J]. Trends Immunol, 2009, 30(2):91-99.
[39] Potiron V, Nasarre P, Roche J, et al. Semaphorin signaling in the immune system[J]. Adv Exp Med, 2007, 600(8):132-144.
[40] Adams RH, Eichmann A. Axon guidance molecules in vascular patterning[J]. Cold Spring Harb Perspect Biol, 2010, 2(5):a001875.
[41] Neufeld G, Kessler O. The semaphorins: versatile regulators of tumour progression and tumour angiogenesis[J]. Nat Rev Cancer, 2008, 8(8):632-645.
[42] Hayashi M, Nakashima T, Taniguchi M, et al. Osteoprotection by semaphorin 3A[J]. Nature, 2012, 485(7396):69-74.
[43] Fukuda T, Takeda S, Xu R, et al. Sema3A regulates bone-mass accrual through sensory innervations[J]. Nature, 2013, 497(7450):490-493.
[44] Xu R. Semaphorin 3A: A new player in bone remodeling[J]. Cell Adh Migr, 2014, 8(1):5-10.

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