《Journal of Oral and Maxillofacial Surgery》 ›› 2021, Vol. 31 ›› Issue (2): 120-123. doi: 10.3969/j.issn.1005-4979.2021.02.011

• Review • Previous Articles     Next Articles

Bioceramics active elements promotes osteogenesis: A collective review

HAN Xianzhuo1(), JIN Liou2, ZHANG Jingju1()   

  1. 1 Shanghai Engineering Research Centre of Tooth Restoration and Regeneration, 1st Department of Orthodontics, School and Hospital of Stomatology, Tongji University,Shanghai 200072
    2 Department of Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun 130021, Jilin Province, China
  • Received:2020-05-12 Revised:2020-05-27 Online:2021-04-28 Published:2021-04-26

活性元素对生物活性陶瓷促成骨作用的影响研究

韩先卓1(), 金丽欧2, 张京剧1()   

  1. 1 上海牙组织修复与再生工程技术研究中心,同济大学口腔医学院,同济大学附属口腔医院正畸一科,上海 200072
    2 吉林大学口腔医院颌面外科,吉林 长春 130021
  • 通讯作者: 张京剧,教授. E-mail: operezh@163.com
  • 作者简介:

    韩先卓(1991—),女,吉林人,医师,硕士. E-mail:

  • 基金资助:
    国家自然科学基金(8197032356)

Abstract:

Bioactive ceramics have been widely used in repair of bones and teeth. A review of literature shows that some ions released from bioceramics can induce differentiation of stem cells into osteoblasts, which has broad prospects in bone regenerative medicine. Since these ions are released from biodegradable ceramic materials, it is easier to achieve controlled release compared with growth factors. Additioning of bioactive ions into bioceramics has become a new method for enhancing angiogenesis and bone formation. Obviously, the biological reaction of bioceramics depends on many parameters, such as chemical composition, morphology, porosity, and grain size. This article focuses on a review of the role and molecular mechanism of ionic dissolved products released in bioceramics for bone regeneration, and aims to provide new ideas for the design of new generation bioactive ceramics.

Key words: bone tissue engineering, osteogenesis, angiogenesis, bioceramics, ion release

摘要:

生物活性陶瓷已被广泛用于骨骼和牙齿的修复,文献回顾表明,一些离子能够诱导干细胞成骨分化,在骨再生医学中具有广阔的前景。鉴于这些离子从可生物降解的陶瓷材料中释放出来,与生长因子相比,更易实现控释。在生物陶瓷中添加生物活性离子,成为开发具有促血管生成和促成骨等功能的新方法。显然,生物陶瓷的生物反应取决于许多参数,例如化学成分、形貌,孔隙率和晶粒尺寸等,本文侧重于对生物陶瓷中释放的离子溶解产物对骨骼再生的作用和分子机制作一综述,旨在为新一代生物活性陶瓷的设计提供新思路。

关键词: 骨组织工程, 成骨, 成血管, 生物陶瓷, 离子释放

CLC Number: