Research advances of Nrf2 in stomatology

doi:10.3969/j.issn.1005-4979.2022.03.010

Abstract

Abstract:

Nuclear factor E2-related factor 2(Nrf2) is an important protein in the transcription factor family, with a molecular weight of 66 kDa. In recent years, with the progress of research, significant research progresses have been made in the activity regulation, downstream pathway of Nrf2 and its effect on disease development, but few progresses in field of oral diseases are reported. In this paper, the research progress of Nrf2 within the field of oral diseases is reviewed.

Key words: nuclear factor E2-related factor 2, periodontitis, oral cancer

摘要：

核因子E2相关因子2（nuclear factor E2-related factor 2，Nrf2）是转录因子家族中的重要蛋白，其分子量为66 kDa。近年来，在Nrf2的活性调控、下游途径和对疾病发展的影响等方面取得了重大的研究进展，但其在口腔疾病方面的研究进展鲜有报道，本文就Nrf2在口腔疾病方面的研究进展作一综述。

关键词: 核因子E2相关因子2, 牙周炎, 口腔癌

HU Dandan, CHENG Chunan, SU Jiansheng. Research advances of Nrf2 in stomatology[J]. 《Journal of Oral and Maxillofacial Surgery》, 2022, 32(3): 192-195.

胡丹丹, 程楚男, 苏俭生. Nrf2在口腔医学领域的研究进展[J]. 《口腔颌面外科杂志》, 2022, 32(3): 192-195.

/ / Recommend / Download Citations

URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2022.03.010

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2022/V32/I3/192

Figures/Tables 1

References 30

[1]	Moi P, Chan K, Asunis I, et al. Isolation of NF-E2-related factor 2(Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region[J]. PNAS, 1994, 91(21): 9926-9930. doi: 10.1073/pnas.91.21.9926 pmid: 7937919
[2]	Tonelli C, Chio IIC, Tuveson DA. Transcriptional regulation by Nrf2[J]. Antioxid Redox Signal, 2018, 29(17): 1727-1745. doi: 10.1089/ars.2017.7342 URL
[3]	Itoh K, Igarashi K, Hayashi N, et al. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins[J]. Mol Cell Biol, 1995, 15(8): 4184-4193. doi: 10.1128/MCB.15.8.4184 pmid: 7623813
[4]	Guo Y, Yu SW, Zhang CY, et al. Epigenetic regulation of Keap1-Nrf2 signaling[J]. Free Radic Biol Med, 2015, 88: 337-349. doi: 10.1016/j.freeradbiomed.2015.06.013 URL
[5]	Baird L, Swift S, Llères D, et al. Monitoring Keap1-Nrf2 interactions in single live cells[J]. Biotechnol Adv, 2014, 32(6): 1133-1144. doi: 10.1016/j.biotechadv.2014.03.004 pmid: 24681086
[6]	Slots J. Periodontitis: Facts, fallacies and the future[J]. Periodontol 2000, 2017, 75(1): 7-23. doi: 10.1111/prd.2017.75.issue-1 URL
[7]	Onizuka S, Iwata T. Application of periodontal ligament-derived multipotent mesenchymal stromal cell sheets for periodontal regeneration[J]. Int J Mol Sci, 2019, 20(11): 2796. doi: 10.3390/ijms20112796 URL
[8]	Ying SQ, Tan MM, Feng G, et al. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative Stress[J]. Theranostics, 2020, 10(21): 9789-9807. doi: 10.7150/thno.42508 pmid: 32863960
[9]	Liu YL, Yang HX, Wen Y, et al. Nrf2 inhibits periodontal ligament stem cell apoptosis under excessive oxidative stress[J]. Int J Mol Sci, 2017, 18(5): 1076. doi: 10.3390/ijms18051076 URL
[10]	Jia LL, Xiong YX, Zhang WJ, et al. Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway[J]. Exp Cell Res, 2020, 386(2): 111717. doi: 10.1016/j.yexcr.2019.111717 URL
[11]	Huang CC, Zhang CT, Yang PP, et al. Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2/HO-1 signaling pathway[J]. Drug Des Devel Ther, 2020, 14: 4901-4913. doi: 10.2147/DDDT.S269223 URL
[12]	Kim S, Choi SI, Kim GH, et al. Anti-inflammatory effect of Ecklonia cava extract on Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages and a periodontitis rat model[J]. Nutrients, 2019, 11(5): 1143. doi: 10.3390/nu11051143 URL
[13]	Bhattarai G, Poudel SB, Kook SH, et al. Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis[J]. Acta Biomater, 2016, 29: 398-408. doi: S1742-7061(15)30161-6 pmid: 26497626
[14]	Fischhuber KM, Matzinger M, Heiss E. AMPK enhances transcription of selected Nrf2 target genes via negative regulation of Bach1[J]. Frontiers in cell and developmental biology, 2020, 8:628. doi: 10.3389/fcell.2020.00628 pmid: 32760724
[15]	Kanzaki H, Shinohara F, Itohiya K, et al. RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice[J]. FASEB J, 2017, 31(2): 781-792. doi: 10.1096/fj.201600826R pmid: 27836987
[16]	Li J, Li YP, Pan S, et al. Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-κB/NFATc1 signaling pathway[J]. Biochimie, 2019, 156: 129-137. doi: S0300-9084(18)30264-5 pmid: 30213522
[17]	Liu H, Dong YH, Gao YT, et al. Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss[J]. J Cell Physiol, 2019, 234(7): 11009-11022. doi: 10.1002/jcp.27924 pmid: 30548260
[18]	Yamaguchi Y, Kanzaki H, Katsumata Y, et al. Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation[J]. J Cell Mol Med, 2018, 22(2): 1138-1147. doi: 10.1111/jcmm.13367 pmid: 29063666
[19]	Narimiya T, Kanzaki H, Yamaguchi Y, et al. Nrf2 activation in osteoblasts suppresses osteoclastogenesis via inhibiting IL-6 expression[J]. Bone Rep, 2019, 11: 100228.
[20]	Primus CM, Tay FR, Niu LN. Bioactive tri/dicalcium silicate cements for treatment of pulpal and periapical tissues[J]. Acta Biomater, 2019, 96: 35-54. doi: S1742-7061(19)30377-0 pmid: 31146033
[21]	Kim D, Kim H, Kim K, et al. The protective effect of indole-3-acetic acid (IAA) on H2O 2-damaged human dental pulp stem cells is mediated by the AKT pathway and involves increased expression of the transcription factor nuclear factor-erythroid 2-related factor 2(Nrf2) and its downstream target heme oxygenase 1 (HO-1)[J]. Oxid Med Cell Longev, 2017, 2017: 8639485.
[22]	Menegon S, Columbano A, Giordano S. The dual roles of NRF2 in cancer[J]. Trends Mol Med, 2016, 22(7): 578-593. doi: S1471-4914(16)30026-0 pmid: 27263465
[23]	贾宝超, 关键, 戴辛鹏, 等. Nrf2、HO-1在口腔鳞癌组织中的表达及其临床意义[J]. 口腔医学研究, 2017, 33(2): 207-210. doi: 10.13701/j.cnki.kqyxyj.2017.02.022
[24]	吴智华, 朱逸文, 余东升. Nrf2及Keap1蛋白在舌鳞状细胞癌中的表达及临床意义[J]. 临床口腔医学杂志, 2019, 35(12): 715-718.
[25]	付洁, 宿颖, 关晓兵, 等. 三氧化二砷对口腔鳞癌细胞系Nrf2通路的激活作用[J]. 北京口腔医学, 2012, 20(5): 260-265.
[26]	Sharma Y, Bharadwaj M, Srivastava N, et al. In vitro antioxidant activity of defatted seed extracts of Ocimum sanctum on rat PC-12 cells and its inhibitory efficacy with receptors of oral squamous cell carcinoma[J]. Ind Crops Prod, 2020, 154: 112668. doi: 10.1016/j.indcrop.2020.112668 URL
[27]	Panigrahi DP, Bhol CS, Nivetha R, et al. Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway[J]. Int J Biol Macromol, 2020, 155: 1123-1132. doi: S0141-8130(19)35707-1 pmid: 31715238
[28]	de Souza RF, Lovato da Silva CH, Nasser M, et al. Interventions for the management of temporomandibular joint osteoarthritis[J]. Cochrane Database Syst Rev, 2012, 2012(4): CD007261.
[29]	Jiang C, Luo P, Li X, et al. Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation[J]. Cell Stress Chaperones, 2020, 25(3): 395-406. doi: 10.1007/s12192-020-01079-z
[30]	Wati SM, Matsumaru D, Motohashi H. Nrf2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands[J]. Redox Biol, 2020, 36: 101603. doi: 10.1016/j.redox.2020.101603 URL

Please choose a citation manager

Content to export