Langerhans cell histiocytosis involving multiple bones in an adult male: A case report

doi:10.3969/j.issn.1005-4979.2022.03.012

Abstract

Abstract:

Langerhans cell histiocytosis (LCH) is a rare disease. Its etiology is uncertain now and its lesions can involve multiple sites. In this study, a case that an adult male with LCH involving rib, ilium and jaw was presented, and the epidemiological characteristics, etiology, clinical characteristics, diagnosis, treatment and prognosis of this case were discussed in combination with relevant literatures.

Key words: rib, ilium, jaw, Langerhans cell histiocytosis

摘要：

朗格汉斯细胞组织细胞增生症(Langerhans cell histiocytosis, LCH）是一种罕见的疾病，目前病因未明，病变可累及全身多部位。本文报道1例累及肋骨、髂骨及颌骨多处骨组织的LCH的成年男性患者，并结合相关文献对该疾病的流行病学特点、病因、临床特点、诊断、治疗和预后进行讨论。

关键词: 肋骨, 髂骨, 颌骨, 朗格汉斯细胞组织细胞增生症

LIU Yang, LI Longjiang. Langerhans cell histiocytosis involving multiple bones in an adult male: A case report[J]. 《Journal of Oral and Maxillofacial Surgery》, 2022, 32(3): 199-202.

刘洋, 李龙江. 成年男性累及多处骨的朗格汉斯细胞组织细胞增生症1例[J]. 《口腔颌面外科杂志》, 2022, 32(3): 199-202.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2022.03.012

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2022/V32/I3/199

Figures/Tables 6

Figure 1 CT image showing multiple irregular bone destruction of left acetabulum and adjacent left ilium

Figure 2 PET/CT image showing increased metabolism in the left acetabulum and adjacent left ilium

Figure 3 Tomography image showing the right maxilla and bilateral mandible were resorbed in pits, the boundary was still clear, and the edge was not smooth

Figure 4 Image of alveolar bone resorption and root exposure in the molar region of the left mandible during the operation

Figure 5 Postoperative pathological hematoxylin-eosin (HE) staining showed that histiocytes proliferation and diffuse infiltration (×200)

Figure 6 Postoperative pathological HE staining showed that the nuclei of the proliferative tissue cells were large, some mitoses were seen, and some cells had vacuolar degeneration (×400)

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