《Journal of Oral and Maxillofacial Surgery》 ›› 2015, Vol. 25 ›› Issue (4): 276-279. doi: 10.3969/j.issn.1005-4979.2015.04.007

• Clinical Study • Previous Articles     Next Articles

The Prediction Value of Caspase-3 and P53  in the Chemotherapy for Oral Squamous Cell Carcinoma

HU Xiao-hua, HUANG Gui-lin, ZHANG Ni-ni, YI Jie, YAO Li   

  1. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Zunyi Medical College,Zunyi 563003, Guizhou Province, China
  • Online:2015-08-28 Published:2015-12-01

Caspase-3及p53预测口腔鳞癌动脉灌注化疗敏感性的观察

胡小华,黄桂林,张霓霓,易杰,姚礼   

  1. 遵义医学院附属口腔医院颌面外科,贵州   遵义   563003
  • 通讯作者: 黄桂林,教授 E-mail:chaojiehuanghgl@163.com
  • 作者简介:胡小华(1977—),男,副主任医师,硕士. E-mail: hxh2132000@163.com

Abstract: Objective: To evaluate the expression of Caspase-3 and P53 in the tumor tissue and their prediction value for chemotherapy of oral squamous cell carcinoma (OSCC). Methods: 58 patients who had positive Caspase-3 expression and/or  negative p53 expression in OSCC were selected, and treated by two courses of continuous chemotherapies with Cisplatin and 5-Fu through intra-arterial infusion, and then underwent surgical dissections. Changes in tumor size  and clinical pathology were observed. The correlations between the expression difference of Caspase-3 and p53 and the degree of tumor regression were retrospectively analyzed. Results: For the patients with Caspase-3 positive expression/p53 negative expression, the predictive sensitiveness accuracy of complete response to infusion chemotherapy and the predictive accuracy of carcinoma structural damage reached 93.55% and 90.32% respectively. Conclusion: The combined analysis of Caspase-3 and p53 may show positive prediction value in chemotherapy of OSCC.

Key words: Caspase-3, p53, intra-arterial infusion, chemotherapy, chemosensitivity

摘要: 目的:观察Caspase-3及p53预测口腔鳞癌行动脉灌注DF方案(顺铂+5-氟尿嘧啶)化疗疗效的准确性。方法:58例Caspase-3表达阳性和(或)p53表达阴性口腔鳞癌患者,行颞浅动脉插管、DF方案持续灌注化疗2周期后手术治疗。观察化疗前、后,原发肿瘤灶大小及病理学变化,分析Caspase-3及p53表达差异与化疗疗效的关系。结果:Caspase-3表达阳性同时p53表达阴性,对口腔鳞癌动脉灌注化疗完全缓解的预测准确性达93.55%,在病理上预测的准确性达90.32%。结论:应用Caspase-3和p53预测口腔鳞癌动脉灌注DF方案化疗敏感性,简便可靠,值得推广。

关键词: Caspase-3, p53, 动脉灌注, 化疗, 敏感性

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