Abstract: Objective: To prepare pure magnesium anodic oxidation-silane/phytic acid double composite zinc coating, hoping to improve the corrosion resistance and cellular biocompatibility of pure magnesium. Method: To prepare pure magnesium anodic oxidation, anodic oxidation-silane treatment, silane/phytic acid double compound treatment and silane/phytic acid double compound loaded Zn specimens, observing the morphology of the coating surface and analyze the main elements by SEM, detecting the cell proliferation and adhesion ability by CCK-8, detecting the cell adhesion morphology by Confocal laser. Results: There were micropores on the surface of pure magnesium anodizing and the composite treatment played a role in sealing. Zinc loaded with different concentrations increased the cell proliferation and adhesion ability. Anodic oxidation-silane/phytic acid double composite loading Zn 20 g/L could prevent cell fluid immersion and the biocompatibility was the best. Conclusion: Pure magnesium anodizing-silane/phytic acid double composite loading Zn 20 g/L film, cell growth and morphology spread best, significantly promoted the osteoblast proliferation, adhesion ability and biological function expression on the surface of the material.

Key words: pure magnesium, anode oxidation, silane/ phytic acid, zinc content, cell compatibility

摘要： 目的：制备纯镁复合硅烷/植酸载锌膜层，希望可以改善纯镁的耐腐蚀性及其细胞生物相容性。方法：制备纯镁阳极氧化、阳极氧化-硅烷处理、阳极氧化-硅烷/植酸双复合处理及硅烷/植酸双复合载Zn试样，采用扫描电镜观察涂层表面形貌，并进行分析元素，通过CCK-8检测细胞增殖和黏附能力，激光共聚焦检测细胞黏附形态。结果：纯镁阳极氧化表面存在微孔,复合处理起到封孔的作用，载不同浓度锌增加了细胞增殖和黏附能力，其中阳极氧化-硅烷/植酸双复合载Zn 20 g/L可防止细胞液浸入，生物相容性最佳。结论：纯镁阳极氧化-硅烷/植酸双复合载Zn 20 g/L膜层，细胞增长和形态铺展最好，明显促进了成骨细胞在材料表面的增殖、黏附能力及其生物功能表达。

关键词: 纯镁, 阳极氧化, 硅烷/植酸, 锌含量, 细胞相容性

CLC Number: 

• R782

• TB42