Abstract: Fibroblast Growth Factor 23(FGF23) is a secreted protein synthesized by osteocytes and osteoblasts. The mature FGF23 protein is secreted into the blood and regulates phosphate reabsorption and vitamin D metabolism through its main target organ, the kidney, thereby maintaining the body's mineral balance and bone mineralization. Excessive FGF23 in the body can cause hypophosphatemia, abnormal vitamin D metabolism, abnormal growth, rickets and osteomalacia. In contrast, the absence of FGF23 will result in hyperphosphatemia, increased 1,25(OH)2D and soft tissue calcification. The production and activity of FGF23 is influenced by systemic and local factors on its transcriptional level, and is also regulated by post-translational modifications. This article reviewed recent progresses in the structure, function and regulation of FGF23, as well as diseases related to disruption of FGF23.

Key words: Fibroblast Growth Factor 23 (FGF23), calcium and phosphate homeostasis, mineralization

摘要： 成纤维细胞生长因子23（FGF23）是一种由骨细胞和成骨细胞合成的分泌蛋白。成熟的FGF23蛋白被分泌到血液中，通过其主要的靶器官即肾脏来调节磷酸盐的重吸收以及维生素D代谢，从而维持机体的矿物质平衡及骨的矿化程度。体内FGF23过多主要会造成低磷酸盐血症、维生素D代谢异常、生长发育异常、佝偻病、骨软化等。相反，FGF23的缺失则会导致高磷酸盐血症、1,25(OH)2D增多、软组织钙化等。FGF23的产生和活性受到全身及局部因素对其转录水平的影响，此外还受到翻译后修饰的调控。本文主要对FGF23的结构和功能、FGF23的调控、FGF23异常相关的疾病等方面的研究进展进行了综述。

关键词: 成纤维细胞生长因子23（FGF23）；  , 钙磷代谢；  , 矿化

CLC Number: 

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• R782.4