Gingival Metastasis of Intrahepatic Cholangiocarcinoma: Case Report and Literature Review

doi:10.3969/j.issn.1005-4979.2020.04.014

《Journal of Oral and Maxillofacial Surgery》 ›› 2020, Vol. 30 ›› Issue (4): 260-263. doi: 10.3969/j.issn.1005-4979.2020.04.014

• Case Report • Previous Articles

Gingival Metastasis of Intrahepatic Cholangiocarcinoma: Case Report and Literature Review

XU Yi¹^,²(), HE Xiaotong¹^,², DAI Wei¹^,², LI Yining¹^,², HU Ji′an¹^,²()

¹ Department of Pathology, The Affiliated Stomatology Hospital, Zhejiang University School of Medicine
² Key Laboratory of Oral Biomedical Research of Zhejiang Province, Zhejiang University School of Stomatology, Hangzhou 310006, Zhejiang Province, China

Received:2019-11-30 Revised:2020-01-17 Online:2020-08-28 Published:2020-08-21

肝内胆管细胞癌牙龈转移1例及文献回顾

徐懿¹^,²(), 贺晓彤¹^,², 戴薇¹^,², 李怡宁¹^,², 胡济安¹^,²()

¹ 浙江大学医学院附属口腔医院病理科
² 浙江省口腔生物医学研究重点实验室，浙江大学口腔医学院，浙江杭州 310006

通讯作者: 胡济安，主任医师. E-mail:hja@zju.edu.cn
作者简介:
徐懿（1996—），男，浙江衢州人，硕士研究生.E-mail:807845804@qq.com
基金资助:
国家卫生和计划生育委员会科研基金(2016139369); 国家重点专项精准医学项目(2016YFC0902700); 浙江省卫生厅一般科研项目(2017192736)

Abstract

Abstract:

Metastatic cancer in the oral cavity is rare and gingiva is the most common site of it. This article reported a case of intrahepatic cholangiocarcinoma metastasis to gingiva and reviewed the literature about oral metastasis of liver cancer.

Key words: cholangiocarcinoma, liver cancer, metastatic cancer, oral, gingiva

摘要：

口腔中转移癌少见，好发的转移部位为牙龈。本文报道了1例牙龈转移性肝胆管细胞癌的病例，并结合文献回顾了肝癌口腔转移的情况。

关键词: 胆管细胞癌, 肝癌, 转移癌, 口腔, 牙龈

CLC Number:

R739.8

XU Yi, HE Xiaotong, DAI Wei, LI Yining, HU Ji′an. Gingival Metastasis of Intrahepatic Cholangiocarcinoma: Case Report and Literature Review[J]. 《Journal of Oral and Maxillofacial Surgery》, 2020, 30(4): 260-263.

徐懿, 贺晓彤, 戴薇, 李怡宁, 胡济安. 肝内胆管细胞癌牙龈转移1例及文献回顾[J]. 《口腔颌面外科杂志》, 2020, 30(4): 260-263.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2020.04.014

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2020/V30/I4/260

Figures/Tables 5

References 12

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类别	鳞状细胞癌	肝细胞癌	滑膜肉瘤	恶性黑色素瘤
镜下表现	侵袭性生长，巢状和条索状肿瘤细胞，有不同程度的鳞状分化；肿瘤组织具有异质性	肿瘤细胞排列呈梁状、腺管状及实性，细胞大，呈多角形，核居中央，空泡状；胞质呈嗜碱性细颗粒状，常见各种类型胞质内或核内包涵体；可见大片显著多形性的细胞伴有其异型细胞。分级依据与正常肝细胞相似的程度，分为高、中、低分化	具有上皮和间叶的双相性，肿瘤组织中有明显的短梭形细胞，排列呈编织状或鲱鱼骨状	肿瘤细胞呈梭形或上皮样，胞质内见大量黑色素，偶见无色素性恶性黑色素瘤
免疫组织化学结果	CKpan(+)、CK5/6(+)、p63(+)、p40(+)、Vimentin（-）、SMA(-)、S-100(-)、CK（AE1/AE3）(+)	AFP(+)、CK8/18(+)、EMA(+)、CEA(±)、CK（AE1/AE3）（±）	CKpan(+)、CK7(+)、CK14 (+)、CK19(+)、EMA(+)、 Vimentin(+)、S-100（±）	HMB-45(+)、Melan-A (++)、S-100(+)

类别	鳞状细胞癌	肝细胞癌	滑膜肉瘤	恶性黑色素瘤
镜下表现	侵袭性生长，巢状和条索状肿瘤细胞，有不同程度的鳞状分化；肿瘤组织具有异质性	肿瘤细胞排列呈梁状、腺管状及实性，细胞大，呈多角形，核居中央，空泡状；胞质呈嗜碱性细颗粒状，常见各种类型胞质内或核内包涵体；可见大片显著多形性的细胞伴有其异型细胞。分级依据与正常肝细胞相似的程度，分为高、中、低分化	具有上皮和间叶的双相性，肿瘤组织中有明显的短梭形细胞，排列呈编织状或鲱鱼骨状	肿瘤细胞呈梭形或上皮样，胞质内见大量黑色素，偶见无色素性恶性黑色素瘤
免疫组织化学结果	CKpan(+)、CK5/6(+)、p63(+)、p40(+)、Vimentin（-）、SMA(-)、S-100(-)、CK（AE1/AE3）(+)	AFP(+)、CK8/18(+)、EMA(+)、CEA(±)、CK（AE1/AE3）（±）	CKpan(+)、CK7(+)、CK14 (+)、CK19(+)、EMA(+)、 Vimentin(+)、S-100（±）	HMB-45(+)、Melan-A (++)、S-100(+)

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