Research Advance on the Role of Mammalian Lipid Droplets as Immunometabolism Hub

Abstract

Abstract:

Mammalian lipid droplets (LDs), a class of cellular organelles associated with metabolism, are composed of a neutral lipid core encapsulated by a monolayer phospholipid membrane. Initially regarded as static energy reservoirs with simplistic

functions, recent advancements have significantly expanded our understanding of their biogenesis mechanisms and multifunctional roles. Beyond serving as central hubs for intracellular lipid metabolism, LDs actively participate in the pathogenesis of inflammatory and infectious diseases, while playing critical regulatory roles in host immune responses.

This paper provides a review of researches in this area.

Key words:

lipid droplets, lipid metabolism, cellular physiological stress, metabolic reprogramming, innate immunity

摘要：

哺乳动物脂滴(lipid droplets, LDs)是一种与细胞代谢相关的细胞器，由中性脂质核心组成，被单层的磷脂极性膜包裹。LDs 最初被认为仅有相对简单和非动态的能量储备功能，但近期的研究对其生物发生机制和功能的理解取得了重大进展。LDs 不仅是细胞内脂质代谢的调节中枢，还参与炎症和感染性疾病的发生、发展，并在调节宿主免疫反应中发挥重要作用，本文就 LDs 在这些领域中的研究进展作一综述。

关键词:

脂滴, 脂质代谢, 细胞生理应激, 代谢重编程, 先天免疫反应

CLC Number:

R782

WANG Xin, SU Jiansheng.

Research Advance on the Role of Mammalian Lipid Droplets as Immunometabolism Hub

[J]. 《Journal of Oral and Maxillofacial Surgery》.

汪鑫, 苏俭生.

哺乳动物脂滴作为免疫代谢中枢角色的研究进展

[J]. 《口腔颌面外科杂志》.

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