摘要： 目的：探讨口腔癌术后放疗对甲状腺功能的影响。方法：对2015?鄄04—2016-04期间，于我科行口腔癌手术且术后进行放疗的34例患者进行前瞻性研究，测定其放疗前及放疗终，放疗后6个月，放疗后1年时，T3、T4、FT3、FT4及TSH的血清水平。结果：放疗终、放疗后6个月及放疗后1年较放疗前，患者T3、T4、FT3、FT4激素水平均降低，差异有统计学意义（P＜0.05）；放疗后、放疗后6个月、放疗后1年，患者T3、T4、FT3、FT4激素水平随时间降低，但差异无统计学意义（P＞0.05），TSH各组差异均无统计学意义（P＞0.05）。结论：口腔癌患者术后放疗患者有甲状腺功能减退的趋势，放疗术后应将甲状腺功能作为随访项目之一。

关键词: 口腔癌；  , 放疗；  , 甲状腺功能

Abstract: Objective: To study the influence of postoperative radiotherapy on thyroid function in patients with oral cancer. Methods: 34 patients with oral cancer post?鄄operative radiotherapy in our department from April 2015 to April 2016 were retrospectively reviewed. Complete blood picture (CBP), serum levels of TSH, T4, T3, FT4, and FT3 were investigated before radiotherapy, at the end of radiotherapy, six months post radiotherapy, one year post radiotherapy respectively. Results: Serum level of T3, T4, FT3, FT4 hormones decreased significantly at the end of radiotherapy, six months of postoperative radiotherapy, one year of postoperative radiotherapy as compared to those before radiotherapy (P<0.05). After radiation therapy, serum T3, T4, FT3, FT4 levels decreased in a time?鄄dependent manner, with no significant difference(P>0.05). TSH variation was not significant (P>0.05). Conclusion: Postoperative radiotherapy in patients with oral cancer may lead to hypothyroidism. Thyroid function should be taken as one of the items for postoperative follow-up

Key words: oral cancer, radiotherapy, thyroid function

中图分类号: 

• R782

• R581