石墨烯家族生物相容性的研究进展

doi:10.3969/j.issn.1005-4979.2019.03.009

摘要/Abstract

摘要： 石墨烯家族具有优异的光学、电学、力学特性，在材料学、微纳加工、能源、生物医学和药物传递等方面具有广阔的应用前景，被认为是一种未来革命性的材料。近年来，其在生物医学及组织工程领域得到广泛研究，但有关其生物相容性的研究缺乏系统综述和讨论。本文将对石墨烯家族生物相容性的体内、体外研究进行系统综述和讨论。

关键词: 石墨烯； , 氧化石墨烯； , 还原氧化石墨烯； , 生物相容性

Abstract: With excellent optical, electrical and mechanical properties, graphene family has important application prospects in materials science, micro-nano processing, energy, biomedicine and drug delivery, so it is regarded as a revolutionary material in the future. In recent years, it has been widely studied in biomedical and tissue engineering fields. However, the research on biocompatibility is lack of systematic review and discussion. In this paper, the possible factors affecting the biocompatibility of graphene family were reviewed and discussed.

Key words: graphene, graphene oxide (GO), reduced graphene oxide (rGO), biocompatibility

中图分类号:

R782.4

岳广娜，王佐林. 石墨烯家族生物相容性的研究进展[J]. 《口腔颌面外科杂志》, doi: 10.3969/j.issn.1005-4979.2019.03.009.

YUE Guang-na, WANG Zuo-lin. A Review on the Biocompatibility of Graphene Family in vivo/vitro Study[J]. 《Journal of Oral and Maxillofacial Surgery》, doi: 10.3969/j.issn.1005-4979.2019.03.009.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2019/V29/I3/169

参考文献

[1] Novoselov KS, Geim AK, Morozov SV, et al. Electric field effect in atomically thin carbon films[J]. Science, 2004, 306(5696):666-669.
[2] Frster GD, Rabilloud F, Calvo F. Adsorption of metal nanoparticles on carbon substrates and epitaxial graphene: Assessing models for dispersion forces[J]. Phys Rev B, 2015, 91(24):245433.
[3] Shin S R , Li Y C , Jang H L , et al. Graphene-based materials for tissue engineering[J]. Adv Drug Deliv Rev, 2016, 105（Pt B）:255-274.
[4] Reina A, Jia XT, Ho J, et al. Large area, few-layer graphene films on arbitrary substrates by chemical vapor deposition[J]. Nano Lett, 2009, 9(1):30-35.
[5] Zheng C, Zhou XF, Cao HL, et al. Edge-enriched porous graphene nanoribbons for high energy density supercapacitors[J]. J Mater Chem A, 2014, 2(20):7484.
[6] Xian JJ, Li DZ, Chen J, et al. TiO2 nanotube array-graphene-CdS quantum dots composite film in Z-scheme with enhanced photoactivity and photostability[J]. ACS Appl Mater Interfaces, 2014, 6(15):13157-13166.
[7] Panchakarla LS, Subrahmanyam KS, Saha SK, et al. Synthesis, structure, and properties of boron- and nitrogen-doped graphene[J]. Adv Mater, 2009，21(46):4726-4730.
[8] Kim J, Kim YR, Kim Y, et al. Graphene-incorporated chitosan substrata for adhesion and differentiation of human mesenchymal stem cells[J]. J Mater Chem B, 2013, 1(7):933.
[9] Wang K, Ruan J, Song H, et al. Biocompatibility of graphene oxide[J]. Nanoscale Res Lett, 2011, 6(1):8.
[10] Chang YL, Yang ST, Liu JH, et al. In vitro toxicity evaluation of graphene oxide on A549 cells[J]. Toxicology Letters, 2011, 200(3):201-210.
[11] Sayyar S, Murray E, Thompson BC, et al. Covalently linked biocompatible graphene/polycaprolactone composites for tissue engineering[J]. Carbon, 2013, 52:296-304.
[12] Murray E, Thompson BC, Sayyar S, et al. Enzymatic degradation of graphene/polycaprolactone materials for tissue engineering[J]. Polym Degrad and Stabil, 2015, 111:71-77.
[13] Zhang YB, Ali SF, Dervishi E, et al. Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells[J]. ACS Nano, 2010, 4(6):3181-3186.
[14] Akhavan O, Ghaderi E. Flash photo stimulation of human neural stem cells on Graphene/TiO2 heterojunction for differentiation into neurons[J]. Nanoscale, 2013, 5(21):10316-10326.
[15] Lin MM, Zou RT, Shi HY, et al. Ocular biocompatibility evaluation of hydroxyl-functionalized graphene[J]. Mater Sci Eng C Mater Biol Appl, 2015, 50:300-308.
[16] Akhavan O, Ghaderi E, Esfandiar A. Wrapping bacteria by graphene nanosheets for isolation from environment, reactivation by sonication, and inactivation by near-infrared irradiation[J]. J Phys Chem B, 2011, 115(19):6279-6288.[PubMed]
[17] Das S, Singh S, Singh V, et al. Oxygenated functional group density on graphene oxide: its effect on cell toxicity[J]. Particle Particle Systems Characterization, 2013, 30(2):148-157.
[18] Liao KH, Lin YS, Macosko CW, et al. Cytotoxicity ofgraphene oxide and graphene in human erythrocytes and skin fibroblasts[J]. ACS Appl Mater Interfaces, 2011, 3(7):2607-2615.
[19] Liu XT, Mu XY, Wu XL, et al. Toxicity of multi-walled carbon nanotubes, graphene oxide, and reduced graphene oxide to zebrafish embryos[J]. Biomed Environ Sci, 2014, 27(9):676-683.
[20] Zhang WD, Wang C, Li ZJ, et al. Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism[J]. Adv Mater Weinheim, 2012, 24(39):5391-5397.
[21] Zhang WD, Yan L, Li M, et al. Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells[J]. Toxicol Lett, 2015, 237(2):61-71.
[22] Mu QX, Su GX, Li LW, et al. Size-dependent cell uptake of protein-coated graphene oxide nanosheets[J]. ACS Appl Mater Interfaces, 2012, 4(4):2259-2266.
[23] Akhavan O, Ghaderi E, Akhavan A. Size-dependent genotoxicity of graphene nanoplatelets in human stem cells[J]. Biomaterials, 2012, 33(32): 8017-8025.
[24] Li N, Zhang Q, Gao S, et al. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells[J]. Sci Rep, 2013, 3:1604.
[25] Jiang ZY, Song Q, Tang ML, et al. Enhanced migration of neural stem cells by microglia grown on a three-dimensional graphene scaffold[J]. ACS Appl Mater Interfaces, 2016, 8(38):25069-25077.
[26] Li XR, Liang H, Sun J, et al. Electrospun collagen fibers with spatial patterning of SDF1α for the guidance of neural stem cells[J]. Adv Healthc Mater, 2015, 4(12):1869-1876.
[27] Alsayed Y, Ngo H, Runnels J, et al. Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma[J]. Blood, 2007, 109(7):2708-2717.
[28] Wilczek P, Major R, Lipinska L, et al. Thrombogenicity and biocompatibility studies of reduced graphene oxide modified acellular pulmonary valve tissue[J]. Mater Sci Eng C Mater Biol Appl, 2015, 53:310-321.
[29] Singh SK, Singh MK, Nayak MK, et al. Thrombus inducing property of atomically thin graphene oxide sheets[J]. ACS Nano, 2011, 5(6):4987-4996.
[30] He C, Shi ZQ, Cheng C, et al. Graphene oxide and sulfonated polyanion co-doped hydrogel films for dual-layered membranes with superior hemocompatibility and antibacterial activity[J]. Biomater Sci, 2016, 4(10):1431-1440.
[31] Geng H, Dai JY, Li JH, et al. Antibacterial ability and hemocompatibility of graphene functionalized germanium[J]. Sci Rep, 2016, 6:37474.
[32] Singh SK, Singh MK, Kulkarni PP, et al. Amine-modified graphene: thrombo-protective safer alternative to graphene oxide for biomedical applications[J]. ACS Nano, 2012, 6(3):2731-2740.
[33] Nonckreman CJ, Fleith S, Rouxhet PG, et al. Competitive adsorption of fibrinogen and albumin and blood platelet adhesion on surfaces modified with nanoparticles and/or PEO[J]. Colloids Surf B Biointerfaces, 2010, 77(2):139-149.
[34] Kenry, Loh KP, Lim CT. Molecular hemocompatibility of graphene oxide and its implication for antithrombotic applications[J]. Small, 2015, 11(38):5105-5117.
[35] Shao WL, He JX, Wang Q, et al. Biomineralized poly(l-lactic-co-glycolic acid)/graphene Oxide/Tussah silk fibroin nanofiber scaffolds with multiple orthogonal layers enhance osteoblastic differentiation of mesenchymal stem cells[J]. ACS Biomater Sci Eng, 2017, 3(7):1370-1380.
[36] Duch MC, Budinger GR, Liang YT, et al. Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung[J]. Nano Lett, 2011, 11(12):5201-5207.
[37] Zhang XY, Yin JL, Peng C, et al. Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration[J]. Carbon, 2011, 49(3):986-995.
[38] Zha YY, Chai RJ, Song Q, et al. Characterization and toxicological effects of three-dimensional graphene foams in rats in vivo[J]. J Nanopart Res, 2016, 18(5):122.
[39] Li B, Zhang XY, Yang JZ, et al. Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection[J]. Int J Nanomedicine, 2014, 9:4697-4707.
[40] Yang K, Wan JM, Zhang S, et al. In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice[J]. ACS Nano, 2011, 5(1):516-522.

选择文件类型/文献管理软件名称

选择包含的内容