初级纤毛与干细胞分化及牙发育相关研究进展

doi:10.3969/j.issn.1005-4979.2019.04.009

摘要/Abstract

摘要： 初级纤毛是突出于细胞表面的一种特殊细胞器，由一根轴丝及包绕在其周围特化的细胞膜和基质组成，具有感受外界机械刺激和生物化学信号的功能。初级纤毛在干细胞自我更新，谱系分化和命运决定中均发挥重要作用。发育中的牙胚上皮和间充质细胞大多具有初级纤毛，而且纤毛的长度随着发育进程出现显著的变化。近年来，初级纤毛在牙发育及牙间充质干细胞分化中的作用逐渐受人关注，深入了解该方面的研究进展有望加深对牙发育机理的认识，以及促进牙再生领域的发展。

Abstract: Primary cilia, a special organelle protruding from the cell surface, consisting of a spindle filament and a specialized membrane and matrix surrounding it, which have the function of sensing external mechanical stimulation and biochemical signals. Primary cilia play an important role in stem cell self-renewal, lineage differentiation and fate decision. Most of the epithelial and mesenchymal cells of developing tooth germ have primary cilia, and the length of cilia changes significantly during the development process. In recent years, the role of primary cilia in the development of teeth and the differentiation of mesenchymal stem cells has attracted more attention. Further research in this area will deepen the understanding of the tooth growth mechanism and promote the development of tooth regeneration.

Key words: primary cilia, dental mesenchymal stem cells, tooth development

中图分类号:

R782

周爽，周婷婷（综述），孙瑶（审校）. 初级纤毛与干细胞分化及牙发育相关研究进展[J]. 《口腔颌面外科杂志》, doi: 10.3969/j.issn.1005-4979.2019.04.009.

ZHOU Shuang, ZHOU Ting-ting, SUN Yao. Recent Advances on Primary Cilia in Stem Cell Differentiation and Tooth Development[J]. 《Journal of Oral and Maxillofacial Surgery》, doi: 10.3969/j.issn.1005-4979.2019.04.009.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2019/V29/I4/230

参考文献

[1] Anna T. Bone development: overview of bone cells and signaling[J]. Curr Osteoporos Rep, 2011, 9(4): 264-273.

[2] Derouen MC, Oro AE. The primary cilium: a small yet mighty organelle[J]. J Invest Dermatol, 2009, 129(2): 264-265.

[3] Eggenschwiler JT, Anderson KV. Cilia and developmental signaling[J]. Annu Rev Cell Dev Biol, 2007, 23: 345-373.

[4] Satir P, Christensen S T. Overview of structure and function of mammalian cilia[J]. Annu Rev Physiol, 2007, 69: 377-400.

[5] Pazour GJ, Wilkerson CG, Witman GB. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)[J]. J Cell Biol, 1998, 141(4): 979-992.

[6] Christensen ST, Pedersen LB, Schneider L, et al. Sensory cilia and integration of signal transduction in human health and disease[J]. Traffic, 2007, 8(2): 97-109.

[7] Christensen ST, Pedersen SF, Satir P, et al. Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair[J]. Curr Top Dev Biol, 2008, 85: 261-301.

[8] Praetorius HA, Leipziger J. Released nucleotides amplify the cilium-dependent, flow-induced [Ca2+]i response in MDCK cells[J]. Acta Physiol (Oxf), 2009,197(3):241-251.

[9] Masyuk A I, Masyuk T V, Larusso N F. Cholangiocyte primary cilia in liver health and disease[J]. Dev Dyn, 2008, 237(8): 2007-2012.

[10] Kuhara A, Okumura M, Kimata T, et al. Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans[J]. Science, 2008, 320(5877): 803-807.

[11] Insinna C, Besharse JC. Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors[J]. Dev Dyn，2008，237(8):1982–1992.

[12] Christensen ST, Voss JW, Teilmann SC, et al. High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts[J]. Cell Biol Int， 2005，29(5):347–351.

[13] Bangs FK, Schrode N, Hadjantonakis AK, et al. Lineage specificity of primary cilia in the mouse embryo[J]. Nat Cell Biol, 2015, 17(2):113–122.

[14] Vestergaard ML, Awan A, Warzecha CB, et al. Immunofluorescence microscopy and mRNA analysis of human embryonic stem cells (hESCs) including primary cilia associated signaling pathways[J]. Methods Mol Biol, 2016, 1307:123-140.

[15] Jang J, Wang Y, Lalli MA, et al. Primary cilium-autophagy-Nrf2 (PAN) axis activation commits human embryonic stem cells to a neuroectoderm Fate[J]. Cell, 2016, 165(2):410-420.

[16] Bodle JC, Rubenstein CD, Phillips ME, et al. Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis[J]. PLoS One, 2013, 8(5):e62554.

[17] Marion V, Stoetzel C, Schlicht D, et al. Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation[J]. Proc Natl Acad Sci U S A, 2009, 106(6):1820-1825.

[18] Dalbay MT, Thorpe SD, Connelly JT, et al. Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1r onto the primary cilium associated with cilia elongation[J]. Stem Cells, 2015, 33(6):1952-1961.

[19] Liu Z, Tu H, Kang Y, et al. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish[J]. Nat Commun, 2019, 10(1):1839.

[20] Paridaen JT, Wilsch-Br?覿uninger M, Huttner WB. Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division[J]. Cell, 2013, 155(2):333-344.

[21] Tong CK, Han YG, Shah JK, et al. Primary cilia are required in a unique subpopulation of neural progenitors[J]. Proc Natl Acad Sci U S A, 2014, 111(34): 12438-12443.

[22] Hampl M, Cela P, Szabo-Rogers HL, et al. Role of primary cilia in odontogenesis[J]. J Dent Res, 2017, 96(9): 965-974.

[23] Brugmann SA, Allen NC, James AW, et al. A primary cilia-dependent etiology for midline facial disorders[J]. Hum Mol Genet, 2010, 19(8): 1577-1592.

[24] Forsythe E, Beales PL. Bardet-Biedl syndrome[J]. European Journal of Human Genetics, 2013, 21(1): 8-13.

[25] Blacque O E, Leroux M R. Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport[J]. Cell Mol Life Sci, 2006, 63(18): 2145-2161.

[26] Andersson E M, Axelsson S, Gjolstad L F, et al. Taurodontism: a minor diagnostic criterion in Laurence-Moon/Bardet-Biedl syndromes[J]. Acta Odontol Scand, 2013, 71(6): 1671-1674.

[27] Borgstr?觟m M K, Riise R, Tornqvist K, et al. Anomalies in the permanent dentition and other oral findings in 29 individuals with Laurence‐Moon‐Bardet‐Biedl syndrome[J]. J Oral Pathol Med, 1996, 25(2): 86-89.

[28] Beales P, Elcioglu N, Woolf A, et al. New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey[J]. J Med Genetics, 1999, 36(6): 437-446.

[29] Qin J, Lin Y, Norman R X, et al. Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components[J]. Proc Nati Acad Sci U S A, 2011, 108(4): 1456-1461.

[30] Baujat G, Le Merrer M. Ellis-van Creveld syndrome[J]. Orphanet J Rare Dis, 2007, 2:27.

[31] Balic A, Aguila HL, Caimano MJ, et al. Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars[J]. Bone, 2010, 46(6): 1639-1651.

[32] Gronthos S, Brahim J, Li W, et al. Stem cell properties of human dental pulp stem cells[J]. J Dent Res, 2002, 81(8): 531-535.

[33] Miura M, Gronthos S, Zhao M, et al. SHED： stem cells from human exfoliated deciduous teeth[J]. Proc Natl Acad Sci U S A, 2003, 100(10): 5807-5812.

[34] Sharpe PT. Dental mesenchymal stem cells[J]. Development, 2016, 143(13): 2273-2280.

[35] Wang X, Sha XJ, Li GH, et al. Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells[J]. Arch Oral Biol. 2012,57(9):1231-1240.

[36] Zhang H, Takeda H, Tsuji T, et al. Loss of function of Evc2 in dental mesenchyme leads to hypomorphic enamel[J]. J Dent Res, 2017, 96(4): 421-429.

[37] Yuan X, Cao X, Yang S. IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development[J]. Cell Death Dis, 2019, 10(2):63.

[38] Martínez C, Smith P C, Rodriguez J P, et al. Sonic hedgehog stimulates proliferation of human periodontal ligament stem cells[J]. J Dent Res, 2011, 90(4): 483-488.

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