BMPs对脂肪干细胞成骨分化作用的研究进展

doi:10.3969/j.issn.1005-4979.2015.05.016

摘要/Abstract

摘要： 脂肪干细胞（ADSCs）具有成骨分化潜能，BMPs可以通过其信号通路产生协同作用。然而，BMPs信号在ADSCs成骨过程中作用机理尚不明确。通过增强BMPs信号，研究人员可运用多种方法促进脂肪干细胞向成骨方向分化。本文将BMPs在脂肪干细胞成骨分化中的作用进行综述。

关键词: BMPs； , 脂肪干细胞； , 骨生成

Abstract: Adipose tissue-derived stem cells（ADSCs） have potential of differentiating to osteogenesis. During the process, BMPs have synergistic effects to promote the mesenchymal stem cells to osteogenesis differentiation through BMPs signaling. However, it remains unclear how the pleiotropic BMPs control osteogenic commitment of ADSCs. Various active agents and methods have been used to enhance and accelerate the osteogenesis of ADSCs through promoting BMP signaling. In this review, we focus on the roles of BMPs in the osteogenesis of ADSCs.

Key words: BMPs, adipose tissue-derived stem cells, osteogenesis

中图分类号:

R782.4

厉超元（综述）王佐林（审校）. BMPs对脂肪干细胞成骨分化作用的研究进展[J]. 《口腔颌面外科杂志》, 2015, 25(5): 383-.

LI Chao-yuan, WANG Zuo-lin. Roles of BMPs in the Osteogenesis of Adipose-Derived Stem Cells[J]. 《Journal of Oral and Maxillofacial Surgery》, 2015, 25(5): 383-.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2015/V25/I5/383

参考文献

[1] Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies[J]. Tissue Eng, 2001,7(2): 211-228.

[2] Konno M, Hamabe A, Hasegawa S, et al. Adipose-derived mesenchymal stem cells and regenerative medicine[J]. Develop Growth Differ, 2013, 55(3):309-318.

[3] Zhu XS, Shi W, Tai WP, et al. The comparition of biological characteristics and multilineage differentiation of bone marrow and adipose derived mesenchymal stem cells [J]. Cell Tissue Res, 2012,350(2):277-287.

[4] Madhu V, Kilanski A, Reghu N, et al. Expression of CD105 and CD34 receptors controls BMP-induced in vitro mineralization of mouse adipose-derived stem cells but does not predict their in vivo bone-forming potential[J]. J Orthop Res, 2015, 33(5):625-632.

[5] E LL, Xu LL, Wu X, et al. The interactions between rat-adipose-derived stromal cells, recombinant human bone morphogenetic protein-2, and beta-tricalcium phosphate play an important role in bone tissue engineering [J]. Tissue Eng Part A, 2010,16(9): 2927-2940.

[6] Tobita M. Adipose-derived stem cells in dentistry [J]. J Oral Biosci, 2013,55(3):122-126.

[7] Zhang X, Guo J, Zhou YS, et al. The roles of bone morphogenetic proteins and their signaling in the osteogenesis of adipose-derived stem cells[J]. Tissue Eng Part B, 2014,20(1): 84-92.

[8] Bodle JC, Rubenstein CD, Phillips ME, et al. Primary Cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis[J]. PLoS One, 2013,8(5): e62554.

[9] Levi B, Hyun JS, Nelson ER, et al. Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair [J]. Stem Cells, 2011,29(12):2018-2029.

[10] Guo J, Wu G. The signaling and functions of heterodimeric bone morphogenetic proteins [J]. Cytokine Growth Factor Rev, 2012,23(1-2):61-67.

[11] Kugimiya F, Yano F, Ohba S, et al. Mechanism of osteogenic induction by FK506 via BMP/Smad pathways[J]. Biochem Biophys Res Commun, 2005,338(2):872-879.

[12] Huang H, Song TJ, Li X, et al. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage [J]. Proc Natl Acad Sci U S A, 2009, 106(31):12670-12675.

[13] Mizrahi O, Sheyn D, Tawackoli W, et al. BMP-6 is more efficient in bone formation than BMP-2 when overexpressed in mesenchymal stem cells[J]. Gene Ther, 2013, 20(4):370-377.

[14] Lin L, Shen Q, Wei X, et al. Comparison of osteogenic potentials of BMP4 transduced stem cells from autologous bone marrow and fat tissue in a rabbit model of calvarial defects [J]. Calcif Tissue Int, 2009, 85(1):55-65.

[15] Vicente Lopez MA, Vazquez Garcia MN, Entrena A, et al. Low doses of bone morphogenetic protein 4 increase the survival of human adipose-derived stem cells maintaining their stemness and multipotency[J]. Stem Cells Dev, 2011,20(6):1011-1019.

[16] Shiraishi T, Sumita Y, Wakamastu Y, et al. Formation of engineered bone with adipose stromal cells from buccal fat pad[J]. J Dent Res, 2012, 91(6):592-597.

[17] Panetta NJ, Gupta DM, Lee JK, et al. Human adipose-derived stromal cells respond to and elaborate bone morphogenetic protein-2 during in vitro osteogenic differentiation[J]. Plast Reconstr Surg, 2010,125(2):483-493.

[18] Song I, Kim BS, Kim CS, et al. Effects of BMP-2 and vitamin D3 on the osteogenic differentiation of adipose stem cells[J]. Biochem Biophys Res Commun, 2011, 408(1):126-131.

[19] Levi B, James AW, Nelson ER, et al. Human adipose derived stromal cells heal critical size mouse calvarial defects [J]. PloS One, 2010, 5(7):e11177.

[20] Szpalski C, Nguyen PD, Cretiu VCE, et al. Bony engineering using time-release porous scaffolds to provide sustained growth factor delivery[J]. J Craniofac Surg, 2012, 23(3):638-644.

[21] Khojasteh A, Behnia H, Naghdi N, et al. Effects of different growth factors and carriers on bone regeneration: a systematic review [J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013, 116(6):e405-e423.

[22] Lu Z, Roohani-Esfahani SI, Li J, et al. Synergistic effect of nanomaterials and BMP-2 signalling in inducing osteogenic differentiation of adipose tissue-derived mesenchymal stem cells[J]. Nanomedicine, 2015, 11(1):219-228.

[23] Vila OF, Martino MM, Nebuloni L, et al. Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors [J]. Acta Biomater, 2014, 10(10):4377-4389.

[24] Peterson B, Zhang J, Iglesias R. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue [J]. Tissue Eng Part A, 2005, 11(1-2):120-129.

[25] Liao YH, Chang YH, Sunga LY, et al. Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b [J]. Biomaterials, 2014, 35(18):4901-4910.

[26] Lin CY, Wang YH, Li KC, et al. Healing of massive segmental femoral bone defects in minipigs by allogenic ASCs engineered with FLPo/Frt-based baculovirus vectors [J]. Biomaterials, 2015, 50:98-106.

[27] Behr B, Tang C, Germann G, et al. Locally applied VADSCular endothelial growth factor a increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation[J]. Stem Cells, 2011, 29(2):286-296.

[28] Fan J, Park H, Tan S, et al. Enhanced osteogenesis of adipose derived stem cells with noggin suppression and delivery of BMP-2 [J]. PloS One, 2013, 8(8):e72474.

[29] Levi B, Nelson ER, Hyun JS, et al. Enhancement of human adipose-derived stromal cell angiogenesis through knockdown of a BMP-2 inhibitor[J]. Plast Reconstr Surg, 2012, 129(1):53-66.

[30] Ramasubramanian A, Shiigi S, Lee GK, et al. Non-viral delivery of inductive and suppressive genes to adipose-derived stem cells for osteogenic differentiation[J]. Pharm Res, 2011, 28(6):1328-1337.

[31] Zhou YS, Liu, YS, Tan JG. Is 1, 25-dihydroxyvitamin D3 an ideal substitute for dexamethasone for inducing osteogenic differentiation of human adipose tissue-derived stromal cells in vitro[J]. Chin Med J (Engl), 2006, 119(15):1278-1286.

[32] Wang CZ, Fu YC, Jian SC, et al. Synthesis and characterization of cationic polymeric nanoparticles as simvastatin carriers for enhancing the osteogenesis of bone marrow mesenchymal stem cells[J]. J Colloid Interface Sci, 2014, 432(15):190-199.

[33] Zhou C, Lin Y. Osteogenic differentiation of adipose-derived stem cells promoted by quercetin[J]. Cell Proliferat, 2014, 47(2):124-132.

[34] Quarto N, Senarath-Yapa K, Renda A, et al. TWIST1 Silencing enhances in vitro and in vivo osteogenic differentiation of human adipose-derived stem cells by triggering activation of BMP-ERK/FGF signaling and TAZ upregulation[J]. Stem Cells, 2015, 33(3):833-847.

[35] Zhang X, Guo J, Zhou Y, et al. The roles of bone morphogenetic proteins and their signaling in the osteogenesis of adipose-derived stem cells[J]. Tissue Eng Part B Rev,2014, 20(1):84-92.

[36] Jeon MJ, Kim JA, Kwon SH, et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2- mediated transcription of osteocalcin in osteoblasts[J]. J Biol Chem, 2003, 278(26):23270-23277.

[37] Lee JS, Lee JM, Im GI. Electroporation-mediated transfer of Runx2 and Osterix genes to enhance osteogenesis of adipose stem cells [J]. Biomaterials, 2011, 32(3):760-768.

[38] Bailey AM, Kapur S, Katz AJ. Characterization of adipose-derived stem cells: an update[J]. Curr Stem Cell Res Ther, 2010, 5(2):95-102.

选择文件类型/文献管理软件名称

选择包含的内容