摘要：

γδT细胞是一类主要分布于皮肤、脏器及体腔黏膜等外周组织的非传统T细胞。γδT细胞作为牙周组织中重要的免疫细胞，对维持牙周稳态至关重要。当牙周稳态遭到破坏时，γδT细胞参与牙周炎症进展；在牙周炎修复期，γδT细胞发挥牙周保护作用，介导牙周组织修复再生。本文综述了牙龈γδT细胞的基本特性与主要功能，重点探讨其在牙周炎进展期和修复期的生物学功能，并对γδT细胞在牙周炎症性疾病治疗中的应用前景进行展望。未来研究应致力于解析牙周炎背景下γδT细胞的功能多样性，并探究不同γδT亚群在牙周炎症中的生物治疗应用前景。

关键词: γδT细胞, 牙周炎, 牙周稳态, 骨再生

Abstract:

γδT cells are a subset of unconventional T lymphocytes primarily distributed in peripheral tissues such as the skin, visceral organs, and mucosal cavities. As key immune cells in the periodontal tissue, γδT cells play a crucial role in maintaining periodontal homeostasis. When periodontal homeostasis is disrupted, γδT cells contribute to the progression of periodontal inflammation. During the reparative phase of periodontitis, these cells exert protective effects and mediate the repair and regeneration of periodontal tissues. This review summarizes the fundamental characteristics and primary functions of gingival γδT cells, with a particular focus on their biological roles during the progression and reparative phase of periodontitis. Additionally, it explores the potential therapeutic applications of γδT cells in the management of periodontal inflammatory diseases. Future research should aim to elucidate the functional diversity of γδT cells in the context of periodontitis and investigate the prospects of different γδT cell subsets for biotherapeutic applications in periodontal inflammation.

Key words: γδT cells, periodontitis, periodontal homeostasis, bone regeneration

中图分类号: 

• R782