摘要：

下颌骨自发性骨再生通常是指下颌骨极限节段性缺损区域内，自发形成新生骨并完成骨连接的现象。本文报道了2例行下颌骨节段性切除后，缺损内出现自发性骨再生并成功连接的病例，并对相关文献进行了综述。从1946年首次报道此类病例以来，至今英文文献中仅有51例相关报道，且大多是无意中发现的零散病例报告；国内文献尚未见此类病例报道。目前，关于此种现象的发生原因及机制尚不明确，研究表明该病可能与多种因素相关，包括缺损区骨膜的保留、骨断端的骨再生、患者的年龄、缺损区的固定/制动、局部的炎症刺激及遗传因素等。对于需行下颌骨部分或节段性切除的病例，若条件允许，尽量保留骨膜，有助于自发性骨再生的发生。

关键词: 下颌骨缺损, 下颌骨再生, 骨膜, 下颌骨重建

Abstract:

Spontaneous mandibular bone regeneration is usually defined as a phenomenon that self-formation of new bone in mandibular critical size defects. The aim of this study was to present two cases of spontaneous mandibular bone regeneration after segmental resection and review the literature. Since the first report of such case in 1946, only 51 cases have been reported in the English literature, most of which are isolated reports, and in most cases the phenomenon of bone regeneration are unexpected. Furthermore, none of such cases have been reported in the Chinese literature. While the exact explanation or mechanism of this bone regeneration is not clearly understood. Many predisposing factors, including the presence of the periosteum, presence of stumps or fragments of bone, the age of the patient, post-operative immobilization, local infection and genetic factors, have been suggested. It is suggested that for those patients requiring partial or segmental mandibulectomy, the periosteum should always be preserved if conditions permit for some spontaneous bone regeneration.

Key words: defects of mandible, mandibular bone regeneration, periosteum, reconstruction of mandible

中图分类号: 

• R782