《口腔颌面外科杂志》 ›› 2026, Vol. 36 ›› Issue (5): 416-419. doi: 10.12439/kqhm.1005-4979.2026.05.008

• 综述 • 上一篇    下一篇

炎症小体在牙周炎与动脉粥样硬化中的调控作用

沈紫芸(), 王佐林()   

  1. 上海市同济口腔医院口腔种植科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海 200072
  • 收稿日期:2024-05-24 接受日期:2025-09-06 出版日期:2026-10-28 上线日期:2026-11-03
  • 通讯作者: 王佐林,教授. E-mail:zuolin@tongji.edu.cn
  • 作者简介:
    沈紫芸,博士研究生. E-mail:
  • 基金资助:
    科技部重点研发计划(2018YFE0202200); 国家自然科学基金(82350001); 上海申康医院发展中心临床三年行动计划(SHDC2020CR5015-002)

Regulation effects of inflammasomes on periodontitis and atherosclerosis

SHEN Ziyun(), WANG Zuolin()   

  1. Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China
  • Received:2024-05-24 Accepted:2025-09-06 Published:2026-10-28 Online:2026-11-03

摘要:

炎症小体(inflammasomes)是一种细胞质超分子复合物,作为机体先天免疫的重要组成部分,在识别外源性微生物的入侵或内源性损伤中发挥重要作用。牙周炎与动脉粥样硬化均为慢性炎症性疾病,二者之间的关联性日益受到关注。炎症小体在全身炎症性疾病的发生、发展中具有重要的调控作用,本文将综述在牙周炎与动脉粥样硬化中发挥重要作用的关键炎症小体及其调控作用。

关键词: 炎症小体, 牙周炎, 动脉粥样硬化

Abstract:

Inflammasomes are cytoplasmic supramolecular complexes, important components of the body's innate immune system, playing an important role in recognizing exogenous microbial invasion or endogenous damage signals. Periodontitis and atherosclerosis are both chronic inflammatory diseases, and the association between them has attracted increasing attention. Inflammasomes play important regulatory roles in the development and progression of systemic inflammatory diseases. This article reviews the key inflammasomes and their regulatory mechanisms, which play vital roles in periodontitis and atherosclerosis.

Key words: inflammasome, periodontitis, atherosclerosis

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