破骨细胞是骨吸收细胞，在生理性骨重塑及病理性骨吸收中均发挥重要作用。炎症是导致病理性骨吸收的一大诱因。研究发现，相比生理状态下的破骨细胞，炎症微环境下分化出的破骨细胞起源于特殊标记的前体细胞，且具有更高的骨吸收能力。此外，其还可通过与其他免疫细胞、基质细胞的相互作用进一步调控骨破坏进程，是研究炎症性骨吸收机制及治疗方法的重要切入点。本文旨在对炎症微环境中破骨细胞的分化与功能特点作一综述。

炎症, 破骨细胞, 骨吸收

Osteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption.Inflammation serves as a significant inducer of pathological bone resorption. Studies have shown that compared with homeostatic osteoclasts, osteoclasts that differentiate in an inflammatory microenvironment not only originate from specific osteoclast precursors, but also exhibit enhanced bone-resorbing capacity. Moreover, these inflammation-derived osteoclasts actively regulate bone destruction processes through crosstalk with stromal and immune cells. Therefore, osteoclasts in the inflammatory microenvironment are crucial for understanding the pathogenesis of inflammatory bone loss and developing targeted therapeutic strategies. This article reviews the differentiation mechanisms and functional properties

of osteoclasts under inflammatory conditions.

inflammation, osteoclast, bone resorption