Abstract: Objective: The purpose of this study was to investigate whether the expression of vascular endothelial growth factor C (VEGF-C) and D2-40 are related to metastatic behavior  of oral squamous cell carcinoma (OSCC). Methods: A retrospective review of 43 cases with OSCC were conducted. The cases were separated into metastasis group and non-metastasis group, in addition, 10 specimen of normal oral mucosa were used as control. D2-40 and VEGF-C expression were detected by  immunohistochemistry. Results: Lymphatic vessels in OSCC mainly distributed in the tumor periphery. The expression of lymphatic vessel density (LVD) and VEGF-C in OSCC were significantly higher than those in normal tissue(P<0.05), and they were significantly higher in lymph node metastasis group than in non-metastatic group(P<0.05). Conclusion: The peri-tumoral lymphatic vessels are associated with lymph node metastasis and VEGF-C may related to the generation of lymphatic vessels in OSCC.

Key words:  oral squamous cell carcinoma (OSCC), lymphatic vessel density (LVD), D2-40, VEGF-C, immunohistochemistry

摘要：  目的： 观察口腔鳞癌中D2-40及VEGF-C的表达特点，探讨VEGF-C在肿瘤淋巴管生成及淋巴结转移中的作用。方法： 将43例口腔鳞癌分为淋巴结转移组和无淋巴结转移组，应用免疫组织化学SP法检测D2-40及VEGF-C的表达情况。结果： 口腔鳞癌中的淋巴管主要分布在肿瘤边缘区（肿瘤间质）。癌组织中淋巴管密度及VEGF-C的阳性表达率显著高于正常组织（P<0.05），淋巴结转移组癌灶中淋巴管密度及VEGF-C的阳性表达率显著高于无淋巴结转移组（P<0.05）。结论: 口腔鳞癌肿瘤边缘区淋巴管与淋巴结转移相关，VEGF-C可能参与口腔鳞癌淋巴管的形成。

关键词: 口腔鳞癌, 淋巴管密度, D2-40, VEGF-C, 免疫组织化学

CLC Number: 

• R739.8