《Journal of Oral and Maxillofacial Surgery》 ›› 2012, Vol. 22 ›› Issue (2): 89-91. doi: 10.3969/j.issn.1005-4979.2012.02.004

Previous Articles     Next Articles

 Expression of D2-40 and VEGF-C and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

FENG Zheng-hu1, LI Chun-qing1, ZHANG Xiao-hui1,YANG Lan2,LIU Jin-ying1   

  1. 1. Department of Stomatology·Key Laboratory of Stomatology of State Ethnic Affairs Commission, Medical College of Northwest University for Nationalities, Lanzhou 730030, Gansu Province;
    2. Department of Oral and Maxillofacial Surgery,the Second Hospital,Lanzhou  University,Lanzhou 730030, Gansu Province, China
  • Online:2012-04-28 Published:2012-06-27
  • About author:冯正虎(1968—),男,甘肃人,副教授,硕士.

VEGF-C的表达与口腔鳞癌淋巴结转移的关系

冯正虎1 , 李春青1, 张晓慧1, 杨兰2, 刘金英1   

  1. 1.西北民族大学医学院口腔教研室·口腔医学国家民委重点实验室,甘肃 兰州 730030;
    2.兰州大学第二医院口腔颌面外科,甘肃 兰州 730030
  • 通讯作者: 冯正虎,副教授. E-mail:yxfzh@xbmu.edu.cn

Abstract: Objective: The purpose of this study was to investigate whether the expression of vascular endothelial growth factor C (VEGF-C) and D2-40 are related to metastatic behavior  of oral squamous cell carcinoma (OSCC). Methods: A retrospective review of 43 cases with OSCC were conducted. The cases were separated into metastasis group and non-metastasis group, in addition, 10 specimen of normal oral mucosa were used as control. D2-40 and VEGF-C expression were detected by  immunohistochemistry. Results: Lymphatic vessels in OSCC mainly distributed in the tumor periphery. The expression of lymphatic vessel density (LVD) and VEGF-C in OSCC were significantly higher than those in normal tissue(P<0.05), and they were significantly higher in lymph node metastasis group than in non-metastatic group(P<0.05). Conclusion: The peri-tumoral lymphatic vessels are associated with lymph node metastasis and VEGF-C may related to the generation of lymphatic vessels in OSCC.

Key words:  oral squamous cell carcinoma (OSCC), lymphatic vessel density (LVD), D2-40, VEGF-C, immunohistochemistry

摘要:  目的: 观察口腔鳞癌中D2-40及VEGF-C的表达特点,探讨VEGF-C在肿瘤淋巴管生成及淋巴结转移中的作用。方法: 将43例口腔鳞癌分为淋巴结转移组和无淋巴结转移组,应用免疫组织化学SP法检测D2-40及VEGF-C的表达情况。结果: 口腔鳞癌中的淋巴管主要分布在肿瘤边缘区(肿瘤间质)。癌组织中淋巴管密度及VEGF-C的阳性表达率显著高于正常组织(P<0.05),淋巴结转移组癌灶中淋巴管密度及VEGF-C的阳性表达率显著高于无淋巴结转移组(P<0.05)。结论: 口腔鳞癌肿瘤边缘区淋巴管与淋巴结转移相关,VEGF-C可能参与口腔鳞癌淋巴管的形成。

关键词: 口腔鳞癌, 淋巴管密度, D2-40, VEGF-C, 免疫组织化学

CLC Number: