Abstract: Objective：To analyze whether the expression of high mobility group box 1 protein (HMGB-1) in gingival crevicular fluid (GCF) are associated with the severity of peri-implantitis.   Methods：GCF was sampled from 79 implantation patients including 39 normal peri-implant tissue and 40 peri-implantitis tissues.  HMGB-1，IL-1β，IL-8，and TNF-α levels were analyzed using ABC-ELISA. Clinical parameters were measured to investigate their relationships. Statistical analyses were performed with SPSS 13.0 software. Results：Significant difference of HMGB-1 expression was observed between healthy implant sites and peri-implantitis sites (P<0.01). The expression levels of HMGB-1 showed positive correlation  with those of IL-1β，IL-8, and TNF-α. Conclusion: HMGB-1 cytokine in GCF may be of value as a parameter in diagnosis and prognosis for peri-implantitis.

Key words: correlation coefficient, cytokine, HMGB-1, peri-implantitis

摘要： 目的：检测种植体周围炎患者龈沟液(gingival crevicular fluid, GCF)中高迁移率族蛋白B-1 (high mobility group box l, HMGB-1)的水平，以探讨HMGB-1水平与种植体周围炎间的关系。方法：经患者知情同意，选取行种植手术1年以上的健康种植体39颗和种植体周围炎40颗，共79颗种植体，收集种植体周围GCF，并运用ELISA法检测其中HMGB-1、IL-1β、IL-8、TNF-α的浓度，同时检测种植体周围的临床指标。结果：轻度种植体周围炎组的HMGB-1、IL-1β、IL-8及TNF-α浓度高于健康种植体组，重度种植体周围炎的浓度水平又高于轻度种植体周围炎组，HMGB-1与IL-1β、TNF-α的浓度之间亦存在正相关关系（P<0.01）。结论：种植体周围GCF中HMGB-1水平变化与种植体周围炎的病变程度有关，且与经典炎症因子间存在显著相关性，临床检测GCF中HMGB-1水平可作为诊断种植体周围炎的客观指标。

关键词: 高迁移率族蛋白B-1, 炎症因子, 相关性, 种植体周围炎

CLC Number: 

• R782.13