A Review on MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Osteogenic and Adipogenic Differentiation

doi:10.3969/j.issn.1005-4979.2020.03.011

Abstract

Abstract:

Bone marrow mesenchymal stem cells (BMSCs) are adult stem cells with self-renewal and multipotential differentiation. They can differentiate into osteoblasts and adipocytes, which is regulated by a variety of factors. MicroRNA is a class of highly conserved endogenous non-coding small RNAs widely found in eukaryotes, which controls gene expression through post-transcriptional regulation and participates in the regulation of biological activities and functions of various organisms. Age is one of the important factors influencing osteogenic and adipogenic differentiation of BMSCs, and microRNA plays important roles in the osteogenic and adipogenic differentiation of BMSCs. The present review focuses on the progress in elucidating the roles of microRNA in the osteogenic and adipogenic differentiation of BMSCs.

Key words: bone marrow mesenchymal stem cells, microRNA, aging, osteogenic differentiation, adipogenic differentiation

摘要：

骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）是机体内具有高度自我更新和多向分化潜能的成体干细胞，可分化为成骨细胞和脂肪细胞，其分化方向受到多种因素的影响。MicroRNA是一类广泛存在于真核生物体内高度保守的内源性非编码小RNA，通过转录后调控基因表达，从而参与调控各种生物体的基本生命活动及功能。年龄是影响BMSCs成骨、成脂分化的重要因素之一。MicroRNA在骨髓间充质干细胞成骨、成脂分化中起重要作用，并参与其年龄相关性成骨、成脂分化。本文对microRNA调控BMSCs成骨和成脂向分化的相关因子及信号通路进行了综述。

关键词: 骨髓间充质干细胞, microRNA, 衰老, 成骨分化, 成脂分化

CLC Number:

R329.2
R782

LUO Huanyu, REN Feilong, LIU Cangwei, YAN Guangxing, HU Yue, HAO Xinqing, SHI Ce, SUN Hongchen. A Review on MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Osteogenic and Adipogenic Differentiation[J]. 《Journal of Oral and Maxillofacial Surgery》, 2020, 30(3): 183-186.

罗环宇, 任飞龙, 刘苍维, 闫广兴, 胡月, 郝新青, 史册, 孙宏晨. MicroRNA调控骨髓间充质干细胞成骨和成脂分化的研究进展[J]. 《口腔颌面外科杂志》, 2020, 30(3): 183-186.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2020.03.011

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2020/V30/I3/183

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