Recent Advances of the Epigenetics on Oral Squamous Cell Carcinoma Tumorigenesis

doi:10.3969/j.issn.1005-4979.2016.02.001

Abstract

Abstract: Dysregulation of gene expression is a frequent occurrence in oral squamous cell carcinoma (OSCC). However, accumulating evidence suggests that in contrast to genetics, epigenetic modifications consisting of aberrant DNA methylation, histone modification, and altered expression of miRNAs induce OSCC tumorigenesis and perhaps play more central role in the evolution and progression of this disease. In this article, we provide a comprehensive review of the impact of epigenetics on oral tumorigenesis with a systematic report on DNA methylation, histone modification, and altered expression of miRNAs in the pathogenesis of OSCC.

Key words: oral squamous cell carcinoma, epigenetic mechanisms；DNA methylation；histone modification

摘要： 口腔鳞状细胞癌（OSCC）是最常见的口腔颌面部恶性肿瘤之一，但目前对于OSCC的具体发病机制并不十分清楚。当前的研究认为在OSCC发生发展中的基因变化因素主要包括基因突变与表观遗传修饰异常。表观遗传修饰是可遗传、可逆转的生物学行为，主要包括DNA甲基化、组蛋白修饰、非编码RNA调控等。近来研究发现，表观遗传修饰的改变尤其是DNA甲基化对OSCC的发病过程意义重大。对于表观遗传学修饰改变的进一步探索将有助于我们理解 OSCC的发病机制，该机制将为OSCC的诊断、治疗、预后提供一个新的研究思路，并且为新型抗肿瘤药物的研发工作，提供了新的理论基础。

关键词: 口腔鳞状细胞癌； , 表观遗传修饰； , DNA甲基化； , 组蛋白修饰

CLC Number:

R781.7

ZHANG Bin. Recent Advances of the Epigenetics on Oral Squamous Cell Carcinoma Tumorigenesis[J]. 《Journal of Oral and Maxillofacial Surgery》, 2016, 26(2): 77-82.

张斌. 口腔鳞状细胞癌的表观遗传学研究现状和进展[J]. 《口腔颌面外科杂志》, 2016, 26(2): 77-82.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2016.02.001

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2016/V26/I2/77

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