Abstract:

Objective: To evaluate the effect of concentrated growth factors (CGF) in the repair of distal osseous defect to mandibular second molar after extraction of the impacted mandibular third molar, and to compare the clinical efficacy. Methods: A total of 25 patients (including 50 extraction sites) whose bilateral impacted mandibular third molars require extraction were recruited. This study was a randomized self-control clinical trial utilizing a split-mouth design. After the extraction of mandibular third molars, the ipsilateral side of the extraction site of the same patient was filled with CGF and included in the CGF group, while the contralateral side of the extraction site was not specially treated and included in the control group. Paired t-test was used to compare the changes in clinical efficacy of osseous defect distal to mandibular second molar between the CGF group and the control group from 1 week to 6 months after the operation. Results: At 2 days after operation, the degree of facial swelling in the CGF group was significantly improved compared with that in the control group (P<0.001). At 3 and 6 months after the operation, osseous defect depth (ODD) distal to mandibular second molars of both groups decreased, but ODD change rate and clinical attachment level (CAL) in the CGF group were significantly improved compared with those in the control group (P<0.05). There was no significant difference in the scores of postoperative symptoms severity (PoSSe) scale between the two groups. Conclusion: This study reveals that CGF would be beneficial to improve facial swelling of patients, favoring bone formation and affecting bone remodeling in the distal aspect of mandibular second molars after extraction of impacted mandibular third molars.

Key words: mandibular third molar, concentrated growth factors, mandibular second molar

摘要：

目的：探究应用浓缩生长因子（concentrated growth factors, CGF）对阻生下颌第三磨牙拔除后相邻第二磨牙远中骨缺损修复及临床疗效的影响。方法：收集需拔除双侧下颌第三磨牙的患者25例（共50个拔牙位点），进行自身双侧对照试验。拔除下颌第三磨牙后，于同一患者的一侧拔牙创填入CGF，纳入CGF组；另一侧拔牙创不做特殊处理，纳入对照组。采用配对t检验比较CGF组与对照组术后1周至术后6个月第二磨牙远中骨缺损修复指标及临床疗效的变化和组间差异。结果：术后2 d，CGF组较对照组面部肿胀度明显改善（P<0.001）；术后3、6个月时，2组第二磨牙远中骨缺损深度（osseous defect depth, ODD）均减少，但CGF组骨缺损愈合率和临床附着水平（clinical attachment level, CAL）较对照组明显改善（P<0.05）；2组术后症状严重程度（postoperative symptom severity, PoSSe）量表评分差异无统计学意义。结论：CGF有利于下颌第三磨牙拔除术后第二磨牙远中骨缺损、CAL及患者面部肿胀度的改善。

关键词: 下颌第三磨牙, 浓缩生长因子, 下颌第二磨牙

CLC Number: 

• R782