Research progress on the effect of oral mesenchymal stem cells on skin injury repair and regeneration

doi:10.12439/kqhm.1005-4979.2026.04.011

Abstract

Abstract:

The functional repair of skin injury remains a significant challenge in the clinic. Conventional treatments, such as skin grafting and wound dressings, often fail to achieve functional regeneration. In recent years, stem cell-based therapies have emerged as a promising strategy in this field. Among them, oral mesenchymal stem cells (OMSCs) have attracted considerable attention due to their unique advantages, including easy accessibility, multilineage differentiation capacity, and scarless regenerative potential. These properties make OMSCs a highly promising cell source for skin wound repair. This review summarizes recent advances in the distinctive advantages, underlying mechanisms, and the therapeutic potential of OMSCs in skin injury repair.

Key words: oral mesenchymal stem cells, skin wound healing, immunomodulation, scarless, tissue regeneration

摘要：

皮肤损伤的功能性修复是当前亟待解决的临床难题，皮肤移植、创面敷料等传统治疗手段难以实现皮肤的功能性再生。近年来，干细胞疗法为该领域提供了新的研究方向。其中，口腔来源间充质干细胞（oral mesenchymal stem cells，OMSCs）具有易获取、多谱系分化潜能和无瘢痕修复特性等独特优势，是皮肤损伤修复领域极具潜力的细胞来源。本文综述了OMSCs在皮肤损伤修复中的独特优势、作用机制和应用潜力等最新研究进展。

关键词: 口腔来源间充质干细胞, 皮肤伤口愈合, 免疫调节, 无瘢痕, 组织再生

WANG Huali, YIN Chengcheng, TIAN Wenzhi, WANG Tong, SUN Luoyong, SUN Hongchen. Research progress on the effect of oral mesenchymal stem cells on skin injury repair and regeneration[J]. Journal of Oral and Maxillofacial Surgery(CN), 2026, 36(4): 342-347.

王化丽, 尹程程, 田文志, 王童, 孙泺咏, 孙宏晨. 口腔来源间充质干细胞对皮肤损伤修复再生影响的研究进展[J]. 《口腔颌面外科杂志》, 2026, 36(4): 342-347.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2026.04.011

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2026/V36/I4/342

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