《Journal of Oral and Maxillofacial Surgery》

• Clinical Study •    

Retrospective analysis of factors affecting the prognosis of Bell's palsy: A bicentric study based on data from 95 patients

SIQIN Gaowa1 , LI Chenxi2,3, HUANG Dishu4 , WANG Yue5 , GONG Zhongcheng2
  

  1. (1. Department of Oral Radiology, School / Hospital of Stomatology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; 2. Department of Oral and Maxillofacial Oncology & Surgery, School / Hospital of Stomatology, the First Affiliated Hospital of Xinjiang Medical University, Stomatological Research Institute of Xinjiang Uygur Autonomous Region,
    Urumqi 830054, China; 3. Clinical Medicine Postdoctoral Scientific Research Station, Xinjiang Medical University, Urumqi 830054, China; 4. Department of Neurology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China; 5. Department of Maxillofacial Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001,China)
  • Online:2025-06-12

基于双中心 95 例患者资料回顾性分析影响贝尔面瘫预后的相关因素

斯琴高娃1,李晨曦2,3,黄迪书4,王玥5,龚忠诚2
  

  1. (1. 新疆医科大学第一附属医院(附属口腔医院)口腔影像科,2. 新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所,乌鲁木齐830054;3. 新疆医科大学临床医学博士后科研流动站,乌鲁木齐 830054;4. 重庆医科大学附属儿童医院神经内科,国家儿童健康与疾病临床医学研究中心,中国儿童健康发展与危重症国际科技合作基地,儿童发育疾病研究教育部重点实验室,重庆医科大学附属儿童医院儿研所重点实验室,重庆 400014;5. 新疆维吾尔自治区人民医院颌面外科,乌鲁木齐 830001)

Abstract:

Objectives: To evaluate the clinical prognostic factors affecting the recovery of patients suffered from Bell´s palsy. Methods: Clinical materials from 95 patients that were admitted to the two principal hospitals in Xinjiang Uygur Autonomous Region between January 2010 and January 2024 due to Bell’s palsy were retrospectively analyzed. In addition to assessing
patient’s demographic characteristics, the independent risk factors that could affect clinical prognosis for patients were identified by performing multivariate logistic regression model. The effectiveness of model was assessed by analyzing the receiver operator characteristic (ROC) curve and calculating the area under the curve (AUC). Results: Patients aged from 28 to 77 (average 49.30 ± 6.96) year-old were included, with females (54.7%) and patients over 50 years old (51.6%)
being the majority. Smoking (P = 0.014), hypertension (P = 0.041), diabetes mellitus (P = 0.049) and higher H-B grade (P < 0.001) were associated with incomplete recovery of patients. There was no statistically significant difference (P > 0.05) in the recovery of patients with facial paralysis between receiving physical therapy and different pharmacological interventions.
According to multivariate logistic regression analyses, the presence of smoking (OR = 3.90, P = 0.018), hypertension (OR = 3.02, P = 0.047) and higher H-B grade (OR = 0.11, P = 0.006) were independent prognostic factors for partial recovery in patients with Bell´s palsy. These three parameters indicated good predictive value for poor clinical prognosis in patients with Bell´s palsy, with AUCs of 0.88, 0.84 and 0.81, respectively. Conclusion: Patients treated with corticosteroids alone or in combination with antivirals showed no significant difference in the recovery rate. Similarly, no statistically significant difference was observed between patients who received physiotherapy and those who did not. Smoking, hypertension, and higher House-Brackmann grade were significantly associated with patients’ poor prognosis, such as partial recovery.

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摘要:

目的:评价影响贝尔面瘫患者康复的临床预后因素。 方法:回顾性分析新疆地区 2010年 1 月至 2024 年 1 月因贝尔面瘫接受治疗的 95 例患者的临床资料。除评价患者人口统计学特征外,还通过多元 Logistic 回归分析模型确定影响患者预后的独立危险因子。通过受试者工作特征(receiver operator characteristic,ROC)曲线分析计算曲线下面积(area under curve,AUC)评价模型效能。 结果:纳入患者年龄 28~77 岁,平均年龄(49.30 ± 6.96)岁,女性(54.7%)和年龄 50 岁以上的患者(51.6%)居多。吸烟(P = 0.014)、高血压(P = 0.041)、糖尿病(P = 0.049)及较高的 House-Brackmann 分级(P < 0.001)与患者部分恢复相关。是否接受物理治疗和不同的药物干预对患者面瘫的恢复无明显相关性(P > 0.05)。多元 Logistic回归模型分析结果显示吸烟(OR=3.90,P = 0.018)、高血压(OR = 3.02,P = 0.047)及较高的 House-Brackmann 分级(OR = 0.11,P = 0.006)是贝尔面瘫患者部分恢复的独立预测因素。三者对患者面瘫部分恢复的预测价值较好(AUC吸烟= 0.88,AUC高血压= 0.84,AUC高H-B 分级= 0.81)。结论:本研究发现单独使用皮质类固醇激素或联合使用抗病毒药物治疗的患者在康复率上无显著差异,同样,在接受理疗的患者和未接受理疗的患者之间也无明显统计学差异。吸烟、高血压和较高 House-Brackmann 分级与不良预后(部分恢复)显著相关。

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