摘要：

目的： 探讨分析小唾液腺来源的复发性多形性腺瘤（recurrent pleomorphic adenoma，RPA）的临床病理特点及预后。方法： 回顾性收集2011年1月至2020年12月间就诊于我院的小唾液腺来源RPA患者的临床资料，并结合文献复习分析其临床特点及预后情况。结果： 共收集17例小唾液腺来源的RPA，其中男性5例，女性12例；年龄为14~80岁，中位年龄为52岁；平均复发次数为2.8次，平均复发间隔为7.9年。按发病部位来分，发生于腭部的最为多见（52.9%），其次为颊部（29.4%）。复发肿瘤较大时可引起一定的症状，如骨质吸收、咽腔阻塞及面部膨隆等。17例患者中共计7例（41.2%）出现恶变，其中腭部来源的9例RPA中，有5例（55.6%）发生恶变。手术治疗的预后较好，平均随访5.7年，其中15例（88.2%）患者为无瘤生存状态。结论： 小唾液腺来源的RPA是一种较为少见的临界性肿瘤，好发于腭部，复发间隔时间较长。反复复发的小唾液腺来源的RPA易出现恶变，手术治疗的预后较好。

关键词: 复发性多形性腺瘤, 小唾液腺, 唾液腺肿瘤

Abstract:

Objective: To investigate the clinicopathological features and prognosis of recurrent pleomorphic adenoma (RPA) of minor salivary glands. Methods: The clinical data of patients with RPA of minor salivary glands in our hospital from January 2011 to December 2020 were retrospectively collected. In combination with literature review, the clinicopathological characteristics and prognosis were analyzed. Results: A total of 17 cases of RPA of minor salivary glands were collected, including 5 males and 12 females. The age ranged from 14 to 80 years, with a median age of 52 years. The average recurrence frequency was 2.8 times, and the average recurrence interval was 7.9 years. It was most common in the palate (52.9%), followed by the buccal (29.4%). Large recurrent tumors may cause certain symptoms, such as bone absorption, pharyngeal cavity obstruction and facial swelling. A total of 7 (41.2%) of 17 patients underwent malignant transformation, and 5 (55.6%) of 9 cases in the palate underwent malignant transformation. The prognosis of surgical treatment was good, with an average follow-up of 5.7 years, and 15 patients (88.2%) were tumor-free status. Conclusion: RPA of minor salivary glands is a rare critical tumor, which often occurs in the palate and has a long recurrence interval. RPA of small salivary gland is prone to undergo malignant transformation, and the prognosis of surgical treatment is good.

Key words: recurrent pleomorphic adenoma, minor salivary gland, salivary gland tumors