Kv 3.4在口腔扁平苔藓和口腔鳞状细胞癌中的表达

doi:10.3969/j.issn.1005-4979.2013.06.004

《口腔颌面外科杂志》 ›› 2013, Vol. 23 ›› Issue (6): 420-423. doi: 10.3969/j.issn.1005-4979.2013.06.004

Kv 3.4在口腔扁平苔藓和口腔鳞状细胞癌中的表达

缪克红¹，聂敏海²，宋成成²，宋萍萍²，伍宝琴²

1. 自贡市第一人民医院口腔科，四川自贡 643000； 2. 泸州医学院附属口腔医院口腔内科，四川泸州 640000

出版日期:2013-12-28 发布日期:2014-05-14
作者简介:四川内江人，女，硕士研究生，E-mail: 506744922@qq.com

Expression of KV 3.4 in Oral Lichen Planus and Oral Squamous Cell Carcinoma

MIAO Ke-hong¹, NIE Min-hai², SONG Cheng-cheng², SONG Pin-pin², WU Bao-qin²

1. Department of Stomatology, Zigong Municipal 1st Peoples’ Hospital， Zigong 643000； 2. Department of Oral Medicine, Stomatological Hospital, Luzhou Medical College, Luzhou 640000, Sichuan Province, China

Online:2013-12-28 Published:2014-05-14
Contact: 聂敏海，教授. E-mail:517094363@qq.com

摘要/Abstract

摘要： 目的：研究钾离子通道蛋白kv 3.4在正常口腔黏膜（normal oral mucosa, NOM）、口腔扁平苔藓(oral lichen planus, OLP)、口腔鳞状细胞癌（squamous cell carcinoma, OSCC）中的表达及意义。方法：免疫组织化学技术检测16例NOM、20例OLP和30例OSCC组织中kv 3.4的表达，采用Wilcoxon秩和检验，α=0.05。结果：kv 3.4在OSCC 中的表达强度高于OLP(P<0.05)， kv 3.4在OLP组织的表达高于正常组织(P<0.05)，且糜烂型OLP中的表达高于非糜烂型OLP(P<0.05)，差异均具有统计学意义。结论：kv 3.4可能与OLP及OSCC的发生、发展有一定的关系。

关键词: 口腔扁平苔藓； , 口腔鳞状细胞癌； , kv 3.4

Abstract: Objective: To study the various expression of KV3.4 in normal oral mucosa (NOM), oral lichen planus (OLP), and oral squamous cell carcinoma (OSCC). Methods: 20 OLP specimens, 30 OSCC surgical resection specimens and 16 NOM cases were collected and were immunohistochemically studied by SP methods. Results: The expressions of KV3.4 were more intensive in OLP and OSCC than in NOM tissues(P<0.05); The expression of KV3.4 was higher in OSCC than in OLP tissues(P<0.05). Conclusions: KV 3.4 may be served as a new marker in the differential diagnosis of oral lichen planus and oral squamous cell carcinoma.

Key words: oral lichen planus, oral squamous cell carcinoma, KV 3.4

中图分类号:

R739.85

缪克红1，聂敏海2，宋成成2，宋萍萍2，伍宝琴2. Kv 3.4在口腔扁平苔藓和口腔鳞状细胞癌中的表达[J]. 《口腔颌面外科杂志》, 2013, 23(6): 420-423.

MIAO Ke-hong1, NIE Min-hai2, SONG Cheng-cheng2, SONG Pin-pin2, WU Bao-qin2. Expression of KV 3.4 in Oral Lichen Planus and Oral Squamous Cell Carcinoma[J]. 《Journal of Oral and Maxillofacial Surgery》, 2013, 23(6): 420-423.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2013/V23/I6/420

参考文献

[1] Rudy B, Sen K, Vega-Saenz de Miera, et al. Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21[J]. J Neurosci Res, 1991, 29(3):401-412.

[2]. Yang S B, Major F, Tietze LF, et al. Block of delayed-rectifier potassium channels by reduced haloperidol and related compounds in mouse cortical neurons[J]. J Pharmacol Exp Ther, 2005, 315 (1):352-362.

[3] Leblanc N. Kv3.4, a key signalling molecule controlling the cell cycle and proliferation of human arterial smooth muscle cells[J]. Cardiovasc Res, 2010,86(3):351-352.

[4] Guo L, Tang X, Tian H, et al. Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells[J]. Eur J Pharmacol, 2008,587(1-3):187-195.

[5] Ousingsawat J, Spitzner M, Puntheeranurak S, et al. Expression of voltage-gated potassium channels in human and mouse colonic carcinoma[J]. Clin Cancer Res, 2007,13(3):824-831.

[6] Chang KW, Yuan TC, Fang KP, et al.The increase of voltage-gated potassium channel Kv3.4 mRNA expression in oral squamous cell carcinoma[J]. J Oral Pathol Med, 2003,32(10):606-611.

[7] Lew TS,Chang CS, Fang KP, et al. The involvement of K(v)3.4 voltage-gated potassium channel in the growth of an oral squamous cell carcinoma cell line[J]. J Oral Pathol Med, 2004,33(9):543-549.

[8] Menéndez ST, Rodrigo JP, Allonca E, et al. Expression and clinical significance of the Kv3.4 potassium channel subunit in the development and progression of head and neck squamous cell carcinomas[J]. J Pathol, 2010, 221(4):402-410.

[9] Spitzner M, Ousingsawat J, Scheidt K, et al. Voltage-gated K+ channels support proliferation of colonic carcinoma cells [J]. FASEB J, 2007, 21(1):35-44.

[10] Sofía Tirados Menéndez,Juan P Rodrigo, Eva Allonca, et a1.Expression and clinical significance of the Kv3.4 potassium channel subunit in the development and progression of head and neck squamous cell carcinomas[J]. Pathol,2010,221:402-410.

[11] Wadhwa S, Wadhwa P, Dinda AK, et a1.Differential expression of potassium ion channels in human renal cell carcinoma[J]. International Urology and Nephrology, 2009, 41(2)：251-257.

[12] Quartel A, Turbeville S, Lounsbury D. Current therapy for Lambert-Eaton myasthenic syndrome: development of 3,4-diamino-pyridine phosphatesalt as first-line symptomatic treatment [J]. Curr Med Res Opin ,2010,26: 1363-1375.

[13] Weng Zhan-ping, Wang Bo, Pan Xiao-yu, et al. Voltage-gated K+ channels are associated with cell proliferation and cell cycle of ovarian cancer cell [J]. Gynecol Oncol, 2007, 104(2):455-460.

[14] 张新，吕晓升，漆明等.Egr-1与TNF-α在口腔扁平苔藓病损中表达的研究[J]. 重庆医科大学学报，2012，37（1）：63-66.

选择文件类型/文献管理软件名称

选择包含的内容

Kv 3.4在口腔扁平苔藓和口腔鳞状细胞癌中的表达

Expression of KV 3.4 in Oral Lichen Planus and Oral Squamous Cell Carcinoma

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

本文评价

[1]	贺娟，刘亮，严翔，辛海涛. 下调miR-21表达对口腔鳞状细胞癌细胞增殖的影响[J]. 《口腔颌面外科杂志》, 2017, 27(1): 25-.
[2]	张燕，严明，刘文娟，胡宇华，陈万涛. Wnt1在口腔鳞癌中的表达及其与淋巴结转移关系的研究[J]. 《口腔颌面外科杂志》, 2016, 26(3): 170-175.
[3]	张斌. 口腔鳞状细胞癌的表观遗传学研究现状和进展[J]. 《口腔颌面外科杂志》, 2016, 26(2): 77-82.
[4]	周燕平，雷荣昌. 口腔鳞癌患者唾液中生物学标记物研究进展[J]. 《口腔颌面外科杂志》, 2014, 24(3): 237-.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Kv 3.4在口腔扁平苔藓和口腔鳞状细胞癌中的表达

Expression of KV 3.4 in Oral Lichen Planus and Oral Squamous Cell Carcinoma

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

本文评价