目的：探究延期负重加载条件下纳米氟磷灰石/聚醚醚酮（nFA/PEEK）新型种植材料骨结合效能研究。方法：各10枚PEEK、nFA/PEEK和钛种植体延期植入10条比格犬下颌骨前磨牙区，2个月后树脂冠修复并于3个月末和6个月末随机处死，非脱钙种植体骨组织行X线和CBCT检查，切片HE染色测定骨结合率（bone-to-implant percentage，BIC），荧光标记测定骨矿化沉积率（mineral apposition rate，MAR）。结果：nFA/PEEK种植体影像清晰，3个月末nFA/PEEK的MAR（1.70±0.65） μm/d低于钛（1.90±0.67） μm/d，且两者差异无统计学意义，但nFA/PEEK和钛的MAR均明显高于PEEK（1.37±0.42） μm/d。6个月末nFA/PEEK的MAR（1.55±0.59） μm/d与钛（0.97±0.46） μm/d比较，差异有统计学意义，均明显高于PEEK（1.17±0.46） μm/d。nFA/PEEK与牙槽骨形成良好骨结合。3个月末钛的BIC（71.24%，中位数）与nFA/PEEK（44.96%）、PEEK（36.08%）间，差异均有统计学意义。6个月末钛的BIC（83.77%）高于nFA/PEEK（76.13%）但差异无统计学意义，均明显高于PEEK（56.62%）。结论：nFA/PEEK具有良好生物相容性，具有未来临床应用价值。

Objective: To investigate and evaluate osteogenesis, which nano-fluorapatite polyetheretherketone (nFA/PEEK) implant materials were in the condition of early loading. Methods: Each 10 of PEEK, nFA/PEEK and Ti implants were installed in mandible premolar area of 10 beagle dogs, and then those resin crowns was applied after 2-month healing. Each 5 dogs were randomly sacrificed at the end of 3- and 6-months. Implants and their undecalcified bone tissues were examined by X-ray and CBCT examination. The bone implant contacts (BIC) were measured after HE staining while the mineralization apposition ratio (MAR) were labeled by fluorochromes. Results: nFA/PEEK implant was clearly seen in X-ray and CBCT. At the end of third month, MAR in nFA/PEEK (1.70±0.65) was not found to be significantly lower than Ti (1.90±0.67), meanwhile, both were significantly higher than PEEK (1.37±0.42)． At the end of 6th month, MAR in nFA/PEEK (1.55±0.59) was found to be significantly higher both than Ti (0.97±0.46), and PEEK (1.17±0.46)． nFA/PEEK implant was found to be osseointegrated. At the end of third month, BIC of Ti (71.24%, Median) was not found to be significantly higher than nFA/PEEK (44.96%), which both of them were significantly higher than PEEK (36.08%)． At the end of 6th month, BIC of Ti (83.77%) was not found to be significantly higher than nFA/PEEK (76.13%), which both of them were significantly higher than PEEK (56.62%)． Conclusions: nFA/PEEK implants show higher biocompatibilities. The results of our study may have potential clinical benefits.