摘要： 目的：探索早期负重载荷下纳米氟磷灰石聚醚醚酮（nFA/PEEK）成骨性能。方法：将nFA/PEEK、聚醚醚酮（PEEK）和商业钛柱状种植体各10枚，植入10只比格犬下颌前磨牙拔牙区，2个月后行冠修复，行使咀嚼3个月末和6个月末随机处死获种植体骨标本，行显微CT扫描测定骨静态参数，切片行亚甲基蓝?鄄酸性品红染色观察骨结合。结果：种植体均获得良好的骨结合，切片显示部分牙槽骨深入nFA/PEEK种植体螺纹内，且见成熟骨细胞样细胞和排列规则的新生骨小梁。3个月末nFA/PEEK和钛种植体周围骨密度（BMD）和骨小梁厚度（Tb.Th）均显著高于PEEK组（P<0.05）。6个月末nFA/PEEK和钛种植体的BMD、Tb.Th和骨小梁数量（Tb.N）均显著高于PEEK组（P<0.05）。nFA/PEEK和钛种植体周围骨小梁间隔（Tb.Sp）均显著低于PEEK组（P<0.05）。6个月末nFA/PEEK、钛的BMD和Tb.N均显著高于3个月末（P<0.05）。结论：nFA/PEEK种植体具有与钛相当的静态成骨性能。

关键词: 纳米氟磷灰石聚醚醚酮；  , 种植体；  , 骨静态学；  , 载荷

Abstract: Objective: To study static osteogenesis by nano-fluorapatite polyetheretherketone (nFA/PEEK) implant materials in the condition of early loading. Methods: Each 10 of nFA/PEEK, PEEK, and Ti implants were installed in mandible premolar area of 10 beagle dogs, and the resin crowns was applied after 2-months healing. Each 5 dogs were randomly sacrificed at the end of 3 and 6 months respectively. Implants and their undecalcified bone tissues were cut for Micro-CT examination. Hard tissue slices were performed and stained by methylene blue-acid fuchsin. Results: All implants were found to have some extent of osseointegration. Some new bones were developed into threads of screw in nFA/PEEK implants, where osteoblasts and regular new bone structure were found. Bone mineral density(BMD) and trabecular thickness (Tb.Th) of nFA/PEEK and Ti were significantly higher than that of PEEK at 3--month (P<0.05). BMD, Tb.Th and number of trabecular bone (Tb.N) of nFA/PEEK and Ti were significantly higher than that of PEEK (P<0.05) at 6- month. Trabecular spacing (Tb.Sp) of nFA/PEEK and Ti were significantly lower than that of PEEK (P<0.05). BMD and Tb.N of nFA/PEEK and Ti at 6- month were significantly higher than that at 3- month (P<0.05). Conclusion: The nFA/PEEK dental implant shows excellent static osteogenesis.

Key words: polyetheretherketone, dental implant, static osteogenesis, load

中图分类号: 

• R856.78