摘要： 目的：探索新型复合材料纳米氟磷灰石聚醚醚酮(nano-fluorapatite polyetheretherketone, nFA/PEEK)的生物相容性和促进骨结合的效能。方法：喷砂nFA/PEEK和非喷砂nFA/PEEK种植体各10枚，植入6只Beagle犬后肢胫骨内，同体同侧后肢胫骨上植入喷砂和非喷砂种植体各1枚（其中4只为双后肢，2只为单后肢）。四环素荧光标记，8周和12周各随机处死3只（各含1只单后肢实验犬），获取种植体-骨组织标本（每组各5份样本）。制作骨磨片，苦味酸品红染色，Bio-Quant图像分析软件测定种植体周围骨组织静态学参数、骨结合率(bone to implant percentage, BIC)和骨矿化沉积速率(mineral apposition rate, MAR)。结果：骨组织静态学参数结果证实表面喷砂处理的nFA/PEEK种植体周围骨组织更致密；12周末喷砂nFA/PEEK的BIC组内最高为82.01%，8周末喷砂nFA/PEEK的MAR组内最高为1.49μm/d；8周和12周末喷砂nFA/PEEK的BIC和MAR分别高于对应非喷砂nFA/PEEK种植体(P<0.05)。结论：表面喷砂处理可增强种植体的初期稳定，nFA/PEEK种植体具有良好的生物相容性和成骨效能，具备未来临床应用价值。
关键词:
氟磷灰石； ,
聚醚醚酮； ,
纳米材料； ,
种植体； ,
骨结合； ,
喷砂
Abstract: Objective: The present study was conducted to identify the biocompatibility and osteogenesis efficiency of a sandblasted nano-fluorapatite polyetheretherketone(nFA/PEEK) coated dental implant material. Methods: 6 beagle dogs were used in this study. 10 sandblasted nFA/PEEK and 10 non-sandblasted nFA/PEEK implants were inserted into the left and right tibias, respectively. Animals were randomly divided into two groups. To observe early bone formation , we chose a time-point of 8 and 12 weeks. Each three dogs were randomly sacrificed and their bone tissues were collected. All samples were processed for undecalcified ground sectioning and stained by picric acid and fuchsin. After that, bone tissue static parameter, the bone to implant percentage (BIC) and mineral apposition rate(MAR) were calculated by the Bio-Quant image analysis software. Results: The bones surround the sandblasted nFA/PEEK implants were denser than those of non-sandblasted nFA/PEEK implants. The BIC of sandblasted nFA/PEEK implants at the end of 12 weeks was the highest， which was elevated up to 82.01%. MAR of sandblasted nFA/PEEK was the highest， which was 1.49μm/d at the end of the 8 weeks. Both BIC and MAR of the sandblasted nFA/PEEK implants were found to be respectively higher than their corresponding non-sandblasted nFA/PEEK implants(P<0.05). Conclusion: Sandblasted nFA/PEEK coated implants enhance its initial stability, which is of great clinical value owe to its better biocompatibility and osteogenic characteristics.
Key words:
fluorapatite,
polyetheretherketone(PEEK),
nano-materials,
implant,
osseointegration； sandblast
中图分类号:
崔晶晶1， 李启期1， 魏杰2， 马健1. 喷砂对纳米氟磷灰石聚醚醚酮种植体骨结合影响的实验研究[J]. 《口腔颌面外科杂志》, 2014, 24(1): 16-.
CUI Jing-jing1, LI Qi-qi1, WEI Jie2, MA Jian1. Evaluation of Osteointegration of Nano-fluorapatite Polyetheretherketone Coated Implants[J]. 《Journal of Oral and Maxillofacial Surgery》, 2014, 24(1): 16-.