MicroRNA调控骨髓间充质干细胞成骨和成脂分化的研究进展

doi:10.3969/j.issn.1005-4979.2020.03.011

《口腔颌面外科杂志》 ›› 2020, Vol. 30 ›› Issue (3): 183-186. doi: 10.3969/j.issn.1005-4979.2020.03.011

MicroRNA调控骨髓间充质干细胞成骨和成脂分化的研究进展

罗环宇¹(), 任飞龙¹, 刘苍维¹, 闫广兴¹, 胡月¹, 郝新青¹, 史册¹(), 孙宏晨¹^,²()

¹ 吉林大学口腔医学院病理科，吉林长春 130021
² 中国医科大学附属口腔医学院，辽宁沈阳 110002

收稿日期:2019-12-02 修回日期:2019-12-06 出版日期:2020-06-28 发布日期:2020-06-26
通讯作者: 孙宏晨，教授. E-mail: hcsun@mail.jlu.edu.cn；史册，副教授. E-mail: shice1004@gmail.com
作者简介:
罗环宇（1994—），女，四川广安人，硕士研究生. E-mail: 635318612@qq.com
基金资助:
国家自然科学基金(81920108012); 国家自然科学基金(81970903); 吉林省财政厅项目(JCSZ2019378-6); 吉林省卫生厅项目(2019 Q013); 中国博士后项目(2018T110258); 中国博士后项目(2017M621219)

A Review on MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Osteogenic and Adipogenic Differentiation

LUO Huanyu¹(), REN Feilong¹, LIU Cangwei¹, YAN Guangxing¹, HU Yue¹, HAO Xinqing¹, SHI Ce¹(), SUN Hongchen¹^,²()

¹ Department of Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, Jilin Province
² School and Hospital of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China

Received:2019-12-02 Revised:2019-12-06 Online:2020-06-28 Published:2020-06-26

摘要/Abstract

摘要：

骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）是机体内具有高度自我更新和多向分化潜能的成体干细胞，可分化为成骨细胞和脂肪细胞，其分化方向受到多种因素的影响。MicroRNA是一类广泛存在于真核生物体内高度保守的内源性非编码小RNA，通过转录后调控基因表达，从而参与调控各种生物体的基本生命活动及功能。年龄是影响BMSCs成骨、成脂分化的重要因素之一。MicroRNA在骨髓间充质干细胞成骨、成脂分化中起重要作用，并参与其年龄相关性成骨、成脂分化。本文对microRNA调控BMSCs成骨和成脂向分化的相关因子及信号通路进行了综述。

关键词: 骨髓间充质干细胞, microRNA, 衰老, 成骨分化, 成脂分化

Abstract:

Bone marrow mesenchymal stem cells (BMSCs) are adult stem cells with self-renewal and multipotential differentiation. They can differentiate into osteoblasts and adipocytes, which is regulated by a variety of factors. MicroRNA is a class of highly conserved endogenous non-coding small RNAs widely found in eukaryotes, which controls gene expression through post-transcriptional regulation and participates in the regulation of biological activities and functions of various organisms. Age is one of the important factors influencing osteogenic and adipogenic differentiation of BMSCs, and microRNA plays important roles in the osteogenic and adipogenic differentiation of BMSCs. The present review focuses on the progress in elucidating the roles of microRNA in the osteogenic and adipogenic differentiation of BMSCs.

Key words: bone marrow mesenchymal stem cells, microRNA, aging, osteogenic differentiation, adipogenic differentiation

中图分类号:

R329.2
R782

罗环宇, 任飞龙, 刘苍维, 闫广兴, 胡月, 郝新青, 史册, 孙宏晨. MicroRNA调控骨髓间充质干细胞成骨和成脂分化的研究进展[J]. 《口腔颌面外科杂志》, 2020, 30(3): 183-186.

LUO Huanyu, REN Feilong, LIU Cangwei, YAN Guangxing, HU Yue, HAO Xinqing, SHI Ce, SUN Hongchen. A Review on MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Osteogenic and Adipogenic Differentiation[J]. 《Journal of Oral and Maxillofacial Surgery》, 2020, 30(3): 183-186.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2020/V30/I3/183

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MicroRNA调控骨髓间充质干细胞成骨和成脂分化的研究进展

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