G蛋白偶联雌激素受体1在骨代谢中作用的研究进展

doi:10.3969/j.issn.1005-4979.2023.03.010

《口腔颌面外科杂志》 ›› 2023, Vol. 33 ›› Issue (3): 194-197. doi: 10.3969/j.issn.1005-4979.2023.03.010

G蛋白偶联雌激素受体1在骨代谢中作用的研究进展

冯源(), 王佐林()

上海牙组织修复与再生工程技术研究中心，同济大学口腔医学院，同济大学附属口腔医院口腔种植科，上海　200072

修回日期:2023-05-17 接受日期:2022-03-11 出版日期:2023-06-28 发布日期:2023-06-28
通讯作者: 王佐林，教授.E-mail：zuolin@tongji.edu.cn
作者简介:
冯源，硕士.E-mail：drfengyuan@163.com
基金资助:
科技部重点研发专项(2018YFE020220)

Recent advances of G protein-coupled estrogen receptor 1 in the metabolism of bone

FENG Yuan(), WANG Zuolin()

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Oral Implantology, School and Hospital of Stomatology, Tongji University, Shanghai 200072, China

Revised:2023-05-17 Accepted:2022-03-11 Online:2023-06-28 Published:2023-06-28

摘要/Abstract

摘要：

G蛋白偶联雌激素受体1（G protein-coupled estrogen receptor 1，GPER1）是一种雌激素的膜受体，其通过快速的细胞多效应作用引发下游反应，对成骨细胞的增殖分化产生影响。因此，GPER1在雌激素介导的骨代谢中有着重要作用。本文对GPER1在骨代谢中的作用作了简要总结，包括GPER1在青春期参与骨生长的过程，在机体不同雌激素水平下的骨代谢中体现出的不同功能，以及其与其他受体共同作用参与了骨代谢。

关键词: 雌激素受体, G蛋白偶联雌激素受体1, 雌激素, 骨代谢

Abstract:

The G protein-coupled estrogen receptor 1 (GPER1) is a membrane receptor for estrogen and it plays an important role in estrogen mediated bone metabolism by triggering downstream responses through rapid cellular pleiotropic effects and influencing the proliferation and differentiation of osteoblasts. This article provides a brief summary of the role of GPER1 in bone metabolism, including the involvement of GPER1 in bone growth during puberty, the realization of different functions in bone metabolism at different estrogen levels in the body, and the participation in bone metabolism in cooperation with other receptors.

Key words: estrogen receptor, G protein-coupled estrogen receptor 1, estrogen, bone metabolism

中图分类号:

R782

冯源, 王佐林. G蛋白偶联雌激素受体1在骨代谢中作用的研究进展[J]. 《口腔颌面外科杂志》, 2023, 33(3): 194-197.

FENG Yuan, WANG Zuolin. Recent advances of G protein-coupled estrogen receptor 1 in the metabolism of bone[J]. 《Journal of Oral and Maxillofacial Surgery》, 2023, 33(3): 194-197.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2023/V33/I3/194

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