摘要： 目的：探讨环孢素诱导的牙龈增生（CIGO）与血清亲环素A（CyPA）之间的关系。方法：本研究以73例用环孢素A（CsA）为主要免疫抑制剂抗排异患者为研究对象，经牙龈增生指数(GOI)评价后将患者分为牙龈增生组（GO+）和无牙龈增生组（GO-）。比较两组患者各临床相关因素之间的差异，重点观察血清CyPA浓度与CIGO发生及严重程度的关系。应用SPSS 17.0软件包进行统计检验，P<0.05表示差异有统计学意义。结果：与正常成人相比，肾移植术后服用CsA的患者，血清CyPA浓度显著降低（P=0.003）。其中，GO+组[(0.30±0.16) ng/mL]明显低于GO?鄄组[(0.44±0.34)ng/Ml](P=0.036)，且与牙龈增生的严重程度呈负相关（r=-0.233，P=0.047），但与CsA服药剂量和血清浓度无关（r=0.001, P=0.999; r=0.006, P=0.963）。结论：血清CyPA与CIGO发生密切相关，血清CsA/CyPA比值有望作为CIGO发生风险因素，帮助临床预判牙龈增生的发生。

关键词: 亲环素A, 环孢素, 牙龈增生, 基质金属蛋白酶

Abstract: Objective：The purpose of this study was to investigate serum level of cyclophilin A (CyPA) in relation to the development of cyclosporine A induced gingival overgrowth (CIGO). Methods: 73 renal transplant recipients were enrolled in this study. The degree of gingival overgrowth(GO) was evaluated using gingival overgrowth index (GOI) and the patients were grouped into overgrowth (GO+) and non-overgrowth (GO-). Serum concentration of CyPA was also measured to seek the possible correlation between CyPA level and the severity of GO. SPSS17.0 software was used for the analyses and a P-value <0.05 was considered significant. Results: Serum levels of CyPA were significantly decreased in patients receiving CsA therapy compared with those obtained from controls (P=0.003). Serum CyPA level in GO+ subjects was significantly lower than those in GO- subjects (0.30±0.16 ng/ml vs 0.44±0.34 ng/ml, P=0.036). The decreased CyPA concentration showed an inverse correlation with GOI (r=-0.233, P=0.047). However, there was no relationship between the serum level of CyPA with the dosage and concentration of CsA(r= 0.001, P=0.999; r=0.006, P=0.93). In addition, the patients with GO presented a significantly high plaque index and papilla bleeding index than those without GO (r=0.366, P=0.001; r=0.334, P=0.001). Conclusion: The principal finding of this study is the significant relationship between the level of serum CyPA and the development of GO. Serum CsA and CyPA levels, particularly the ratio of CsA to CyPA, may be valuable markers for predicting the development of GO.

Key words: cyclophilin A, cyclosporine, gingival overgrowth, matrix metalloproteinases

中图分类号: 

• R781.4