髓样细胞表达触发受体?鄄2调控破骨细胞分化的研究进展

doi:10.3969/j.issn.1005-4979.2019.06.010

《口腔颌面外科杂志》

髓样细胞表达触发受体?鄄2调控破骨细胞分化的研究进展

裴庆国,王佐林

上海牙组织修复与再生工程技术研究中心，同济大学口腔医学院·同济大学附属口腔医院种植科，上海 200072

出版日期:2019-12-28 发布日期:2019-12-25
通讯作者: 王佐林，教授. E-mail: zuolin@tongji.edu.cn E-mail:zuolin@tongji.edu.cn
作者简介:裴庆国（1980—），男，山东人，博士研究生. E-mail: dentistpei@126.com
基金资助:
国家自然科学基金面上项目（81670962）；科技部重点研发计划重点专项（2019-08-2023-07）；同济大学中央高校基本业务费专项基金（22120180196）

A Comprehensive Review of Triggering Receptors Expressed on Myeloid Cells-2 on the Regulation of Osteoclasts Differentiation

PEI Qing-guo, WANG Zuo-lin

Department of Implantology, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 20072, China

Online:2019-12-28 Published:2019-12-25

摘要/Abstract

摘要： 髓样细胞表达触发受体-2（triggering receptors expressed on myeloid cells-2, TREM-2）是新近发现的免疫球蛋白受体，对破骨的形成有重要作用。它通过与DAP12（DNAX activating protein of 12 kDa）形成复合体，接受信号，引起系列反应，参与破骨细胞的成熟和分化。本文对TREM-2 / DAP12复合体的形成、作用及有关TREM-2的配体做一综述，以期为颌骨代谢的相关研究提供新思路。

关键词: 髓样细胞表达触发受体-2, 共受体, 破骨细胞

Abstract: TREM-2（triggering receptors expressed on myeloid cells-2） is a newly discovered immunoglobulin receptor, which plays an important role in osteoclast formation. It is involved in the maturation and differentiation of osteoclasts by forming complex with DAP12, receiving signals, causing a series of reactions. In this paper, the formation and function of TREM-2/DAP12 complex and the ligands related to TREM-2 are reviewed, in order to provide new ideas for the study of jaw metabolism.

Key words: TREM-2, co-receptor, osteoclast

中图分类号:

R782
R329.2

裴庆国,王佐林. 髓样细胞表达触发受体?鄄2调控破骨细胞分化的研究进展[J]. 《口腔颌面外科杂志》, doi: 10.3969/j.issn.1005-4979.2019.06.010.

PEI Qing-guo, WANG Zuo-lin. A Comprehensive Review of Triggering Receptors Expressed on Myeloid Cells-2 on the Regulation of Osteoclasts Differentiation[J]. 《Journal of Oral and Maxillofacial Surgery》, doi: 10.3969/j.issn.1005-4979.2019.06.010.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2019/V29/I6/352

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