口腔黏膜下纤维性变的成因及癌变的相关性研究

doi:10.3969/j.issn.1005-4979.2020.04.001

《口腔颌面外科杂志》 ›› 2020, Vol. 30 ›› Issue (4): 195-200. doi: 10.3969/j.issn.1005-4979.2020.04.001

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口腔黏膜下纤维性变的成因及癌变的相关性研究

翦新春(), 高兴, 谭茜

中南大学湘雅医院口腔医学中心口腔颌面外科，中南大学口腔癌前病变研究所，湖南长沙 410008

收稿日期:2020-03-09 修回日期:2020-06-28 出版日期:2020-08-28 发布日期:2020-08-21
通讯作者: 翦新春，教授. E-mail: drjianxinchun@163.com

作者简介:

[专家介绍] 翦新春，中南大学湘雅医院二级教授、一级主任医师、博士研究生导师，湖南省干部保健局核心专家，湘雅名医。现任国际牙医师学院院士，美国弗吉尼亚州立大学医学院客座教授；中华口腔医学会理事会常务理事、中华医学会整形美容外科专业委员会唇腭裂学组副组长；湖南省口腔医学会会长。担任The Scientific Pages of Oral Cancer、Journal of Dentistry and Oral Biology，以及《中华医学美学美容杂志》等国内外23种杂志的编委或特邀编委；Journal of Pathology and Medicine 和Chinese Medicine Journal的特邀审稿人。先后主持“十五”国家科技攻关计划重点项目子项目、国家自然科学基金面上项目6项，美国中华医学会（China Medical Board, CMB）基金、湖南省科技厅自然科学基金及湖南省科技厅科技发展基金等项目12项。共发表学术论文468篇，其中SCI收录论文41篇。主编专著6部、参编专著16部。曾获中华人民共和国教育部科学技术进步奖二等奖1项，中华医学科技进步奖三等奖3项，湖南省科学技术进步奖二等奖1项，湖南省教育厅、湖南省卫生厅及中南大学科技进步奖18项。培养博士及硕士研究生100余名。
翦新春（1951—），男，湖南省安乡人，硕士，教授.

基金资助:
国家自然科学基金项目(81260166); 国家自然科学基金项目(81041052); 国家自然科学基金项目(30572044)

Etiology and Malignant Transformation of Oral Submucous Fibrosis: A Review

JIAN Xinchun(), GAO Xing, TAN Qian

Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, Hunan Province, China

Received:2020-03-09 Revised:2020-06-28 Online:2020-08-28 Published:2020-08-21

摘要/Abstract

摘要：

口腔黏膜下纤维性变（oral submucous fibrosis，OSF）是世界卫生组织（World Health Organization，WHO）国际癌症研究中心（International Agency for Research on Cancer，IARC）认定的口腔黏膜潜在的恶性病变。咀嚼槟榔可引起口腔黏膜下纤维性变，其发病与咀嚼槟榔的频率及时间有着密切的量效依赖关系。本文就口腔黏膜下纤维性变是否是一种口腔癌前病变，咀嚼槟榔导致口腔黏膜潜在的恶性病变，以及国外、中国大陆与台湾地区有关该病的研究作一概述，供口腔科医师参考。

关键词: 口腔黏膜下纤维性变, 口腔黏膜潜在恶性病变, 口腔癌前病变

Abstract:

Oral submucous fibrosis (OSF) was defined as an oral potentially malignant mucous disorders by the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO). Oral submucous fibrosis was led by chewing betel quid and showed a dose-dependent and time-dependent manner. Whether oral submucous fibrosis is a real oral precancerous lesion or oral potentially malignant disorders led by chewing betel quid, this paper summarizes the present knowledge throughout the foreign countries, Chinese mainland, and Taiwan.

Key words: oral submucous fibrosis（OSF）, oral potentially malignant mucous disorders, oral precancerous lesions

中图分类号:

R782
R739.8

翦新春, 高兴, 谭茜. 口腔黏膜下纤维性变的成因及癌变的相关性研究[J]. 《口腔颌面外科杂志》, 2020, 30(4): 195-200.

JIAN Xinchun, GAO Xing, TAN Qian. Etiology and Malignant Transformation of Oral Submucous Fibrosis: A Review[J]. 《Journal of Oral and Maxillofacial Surgery》, 2020, 30(4): 195-200.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2020/V30/I4/195

图/表 3

图1 中国目前流行的2种槟榔咀嚼物注：A. 台湾地区流行的槟榔鲜果嚼块；B. 海南地区流行的槟榔鲜果嚼块；C. 湖南湘潭或其他部分地区流行的干槟榔咀嚼物。

Figure 1 Two popular betel quids at the moment in China

图2 口内咀嚼后的槟榔纤维

Figure 2 Betel quid fibers waste after chewing in the oral cavity

图3 咀嚼槟榔致口腔颊黏膜癌前病变及口腔癌注：A. 患者颊黏膜存在的口腔黏膜下纤维性变和黏膜白斑；B. 右口角疣状白斑、中部颊黏膜上的白斑癌变和翼下颌韧带后方的口腔黏膜下纤维性变，同时存在于患者口腔中。

Figure 3 Chewing betel quid causes oral precancerous lesions and oral cancer on the buccal mucosa

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